Type 2 Diabetes Mellitus Clinical Trial
Official title:
Lifestyle Intervention in Patients With Diabetes Type 2 and the Association With the Gut Microbiota
To investigate whether targeted lifestyle intervention (exercise), induces a change in intestinal fecal microbiota related to improved glycemic control and systemic inflammation in patients with DM type 2.
Diet and exercise are the most beneficial lifestyle interventions in patients with diabetes
mellitus (DM) type 2, causing an increase in glucose tolerance.
One of the mechanisms through which these treatment modalities work might be explained
through changes in the gut microbiota. Recent studies show that the chronic inflammatory
status causing insulin resistance in DM type 2, is triggered by an increase in circulating
bacterial lipopolysaccharide (LPS). Strict lifestyle intervention, such as exercise, so
called Diabetes Bootcamp (DB), may manipulate the gut microbiota, reducing circulating LPS,
causing an improvement of the insulin-mediated
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