Type 2 Diabetes Mellitus Clinical Trial
Official title:
Correlation Between 1,5-anhydroglucitol and Postprandial Hyperglycemia by Continuous Glucose Monitoring System and Clinical Usefulness of 1,5-anhydroglucitol in Well-controlled Diabetic Patients
The aim of this study was to evaluate the correlation between 1,5-Anhydroglucitol in patients with HbA1C <7%, and glycemic excursions as assessed by the continuous glucose monitoring system compared to fructosamine.
1,5-Anhydroglucitol (AG) is a glucose analogue present in the plasma of healthy subjects.
Physiologically, the plasma levels of 1,5-AG are very stable and only a small quantity is
excreted in the urine. It is competitively reabsorbed with glucose in the renal tubules.
Therefore, in the hyperglycemic state where glycosuria is present, glucose competitively
inhibits renal tubular reabsorption of 1,5-AG and consequently the plasma 1,5-AG levels
decrease. When glycemia is normalized and glycosuria is resolved, 1,5-AG levels increase.
The usefulness of 1, 5-AG in reflecting glycemic excursions have been demonstrated in
moderately controlled patients to some extent, although some studies reveal controversial
results.
Therefore, the aim of this study was to evaluate the association of 1,5-AG and postprandial
hyperglycemia determined using the Continuous Glucose Monitoring System (CGMS) in DM
patients with HbA1C<7% and evaluate the usefulness of 1,5-AG as a marker of glycemic control
compared to HbA1C and fructosamine.
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Observational Model: Cohort, Time Perspective: Prospective
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