Traumatic Brain Injury Clinical Trial
Official title:
Pilot Study of Intranasal Nerve Growth Factor for Traumatic Brain Injury(TBI)
Traumatic bain injury(TBI) remains a hidden epidemic involving individuals affected predominantly at a young age who in the most severe cases remain with permanent physical,psychological and cognitive deficits.This study will investigate the therapeutic effects of intranasal Nerve Growth Factor(NGF) in TBI.
Early NGF concentration in the cerebral spinal fluid(CSF)correlates significantly with the
severity of head injury, and NGF upregulation correlates with better neurologic outcomes and
could be useful to obtain clinical and prognostic information in patients with serve TBI.
However, the clinical use of NGF is difficulty associated with delivering them to the CNS
because of the existing of blood-brain barrier(BBB). Intranasal delivery drug is a
noninvasive and convenient novel method bypassing BBB, which results in targeting
therapeutics to the CNS rapidly.
The proposed study is a randomized, double-blind, placebo-controlled trail of NGF, starting
between 24 to 72 hours post TBI, continuing for 2 weeks.
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