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Transgender Persons clinical trials

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NCT ID: NCT06177600 Not yet recruiting - Gender Identity Clinical Trials

TransHealthGUIDE: Transforming Health for Gender-Diverse Youth

Start date: January 22, 2024
Phase: N/A
Study type: Interventional

This is a randomized controlled trial to test the effectiveness of an interactive educational app-based digital intervention that provides knowledge and support to transgender and gender-diverse (TGD) youth ages 15-24 years and their caregivers. The goal of the study is to examine the effects of exposure to the app on TGD youth mental health outcomes. Participants will be randomized to an Immediate Arm (access to a digital platform, plus usual care) or a Deferred Arm (usual care; access to the digital platform at 6 mo). Usual care consists of access to published resources and community support organizations, if available. The list of resources will include contact information for a suicide prevention hotline. For each Arm, the intervention period will last 6 months, followed by 12 months of observation, during which access to the intervention is maintained. Assessments will be performed every 3 months over the 18 month period to document changes in mental health outcomes, and the two groups will be compared. The investigators plan to enroll 500 TGD youth and their caregivers, with at least 50% (250 participants) to identify as Black, Indigenous, People of Color (BIPOC) and 50% (125 TGD youth, 125 caregivers) to be youth-caregiver dyads. Ongoing process reassessments will be performed to maximize effectiveness of the intervention, including focus groups and in-depth interviews with TGD youth, caregivers, and providers, as well as analysis of data collected through the digital platform and participant surveys. Investigators will account for sociodemographic characteristics such as race and ethnicity, age, gender identity, school status, existing mental health conditions, and history of suicidal ideation or attempt. Data will be analyzed across racial minority groups to ensure that the intervention is effective for all racial minorities; if there are discrepancies in effectiveness, additional mixed methods evaluation will be performed to identify and address potential causes.

NCT ID: NCT05927350 Not yet recruiting - Transgender Persons Clinical Trials

Research Participation With Transgender and Gender-Diverse Youth

Start date: April 2024
Phase:
Study type: Observational

Research has historically excluded the participation of transgender and gender-diverse people. The purpose of this research study is to find out about what goes into a transgender and gender-diverse youth's decision to participate in research. The results of this study will be used to improve access to research for transgender and gender-diverse youth and therefore, improve the representation of transgender and gender-diverse youth as research participants in research.

NCT ID: NCT05924217 Recruiting - Cervical Cancer Clinical Trials

Gynecology Beyond Gender: Cervical Cancer Screening in Transgender Men in France

GYDECAT
Start date: January 2, 2024
Phase:
Study type: Observational

In France, cervical cancer screening is the subject of a national screening programme organized for all asymptomatic individuals aged 25 to 65 years with a cervix. The latter contributes greatly to the prevention and early treatment of this disease, whose public health challenge is recognized worldwide. One of the objectives of this programme is to reduce inequalities in access. Transgender men, i.e. individuals assigned to the female gender at birth but identifying with the male gender, are concerned by this screening as long as they still have a cervix, according to the same modalities as for cisgender women. However, they are often excluded from health care, including organized screening programs. Gender change in civil status is one of the obstacles. The provision of gynaecological care is sometimes inadequate. The lack of knowledge of health professionals and the problems of discrimination that transgender people may face reduce the chances of having equitable access. This survey aims to explore the perception that transgender men have of cervical cancer screening and to identify the challenges they face, the obstacles and the levers to access this prevention program.

NCT ID: NCT05865262 Completed - Clinical trials for QT Interval, Variation in

Protocol TRANS and QT Repolarization

QTrans
Start date: November 16, 2021
Phase:
Study type: Observational

The consequences of hormonal treatment in transgender patients are still unknown. Thanks to the retrospective collection of control ECG data before and after hormone therapy, the impact of feminizing and masculinizing hormone treatment on ventricular repolarization in a population of treated transgender people, followed in the Endocrinology department of the Haut- Lévêque in Pessac, will be studied and compared with the cisgender population.

NCT ID: NCT05469204 Recruiting - Transgender Persons Clinical Trials

Effect of Estrogen Treatment on Drug Metabolism and Transport

Start date: November 1, 2022
Phase:
Study type: Observational

This project will evaluate the effect of gender-affirming estrogen treatment on how other medications are processed by the body.

NCT ID: NCT05337865 Not yet recruiting - Transgender Persons Clinical Trials

Transgender Observational Performance

TOP
Start date: May 2022
Phase:
Study type: Observational

The study will evaluate the sports capabilities of transgender women mainly in terms of muscular strength and aerobic capacity (VO2max). The control group will be composed of cisgender women and cisgender men with the same levels of physical activity.

NCT ID: NCT05187442 Completed - Sexual Health Clinical Trials

The Experiences of Erotic and Sexual Risk of Transgender Men: Exploratory Research Design

Start date: January 12, 2022
Phase:
Study type: Observational [Patient Registry]

Transgender male (TM) is the minority and difficult to reach-up group. Therefore, there is a lack of research on private issues involving TM, such as sex, eroticism, and sexual risk behavior. This study focuses on TM as the research participant, based on Milton Mayeroff's caring theory, to understand the TM's erotic culture and the sexual risks behavior, to evaluate the need for subsequent sexual health care. The research method is a mixed methods research of explanatory design, which recruits participants through purposive sampling and respondent-driven sample (RDS) methods. The first stage is an online questionnaire survey. A total of 321 TMs were recruited. The time of online questionnaire is about 10-15 minutes to get a preliminary understanding of the erotic and sexual risk experience of TM in Taiwan. In the second stage, focus groups and in-depth interviews will be conducted, 2 hours of each group and interview. A total of 29 transgender man and women, and non-binary participants were recruited. The recruitment will be stop when the data are saturated. The analysis of both quantitative and qualitative data can get an in-depth understanding of sex, eroticism, and sexual risk, and violence experiences of the participants. The research results are important for improving the awareness and identification of sexual risk and the assessment of sexual health care needs of TM in health care profession. The results also serve as a reference guide for the development of care needs on sexual health care and anti-violence of transgender people, and for the implement of a gender-friendly environment for medical care.

NCT ID: NCT05166083 Recruiting - Gender Dysphoria Clinical Trials

Investigation of the Perceptual and Acoustic Voice in Trans Man

Start date: March 11, 2022
Phase:
Study type: Observational [Patient Registry]

The aim of the study is to follow acoustic and perceptual voice changes in trans men during hormone therapy and to examine the relationship between psychosocial and vocal characteristics and testosterone measured in routine follow-up in accordance with international follow-up guidelines.

NCT ID: NCT05116293 Active, not recruiting - Transgender Persons Clinical Trials

Effect of Testosterone Treatment on Drug Metabolism and Transport

Start date: May 1, 2021
Phase:
Study type: Observational

This project will evaluate the effect of gender-affirming testosterone treatment on how other medications are processed by the body.

NCT ID: NCT04534881 Terminated - Transgender Persons Clinical Trials

Effect of Progesterone on Testosterone Concentrations and Breast Development in Transwomen

Start date: October 20, 2020
Phase: Phase 2
Study type: Interventional

- Purpose. The purpose of this research is study the effect of progesterone therapy on testosterone levels in transwomen who are currently on gender affirming treatment with estradiol. - Duration. It is expected that participation will last for 6 months (24 weeks). - Study Procedures. Participants will be asked to sign an informed consent, complete a medical history, have a physical exam conducted, have a fasting blood sample taken and asked to take a study drug once daily. - Risks. Some of the foreseeable risks or discomforts include temporary discomfort, bleeding, bruising and/or swelling in the arm from blood draw. There are no known direct risks with the use of Progesterone in Transwomen for gender affirming therapy. - Benefits. Some of the possible benefits that may be expected include increase in fat mass, increase in breast size/fullness, decrease in masculine hair patterns.