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Tooth Extraction clinical trials

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NCT ID: NCT04166890 Completed - Drug Effect Clinical Trials

Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia

ECA
Start date: September 4, 2018
Phase: Phase 4
Study type: Interventional

In the complexity of the Dental care the third molar surgery is one of the most common procedures, it is indicated for multiple reasons like infections in root canal, prosthetics or even esthetical purposes. This surgery can be safely performed with the help of local anesthetics, due to their quick action, and reversibility to control pain, reducing possible complications during and after the surgeries. Among the different types of local anesthetics used in dentistry, the articaine bears characteristics that provide some advantages compared to similar anesthetics like Lidocaine, being one of the most used anesthetics worldwide. Different authors have concluded that it is a safe when used in patients at different ages and it is effective as a local anesthetic in the majority of procedures. It is important for dentists to know the differences or similarities of anesthetics in terms of their effects, safety, dosages required in patients undergoing surgical removal of teeth, as well as the mechanism of action and pharmacological properties, in order to take advantage of its benefits and minimize risks. This study aims to test the efficacy and safety of an anesthetic solution, based on the same active molecule, articaine, manufactured by two different commercial houses, one domestic and one international, in order to gather scientific evidence and to show that they are not different. This will provide scientific results to help in the selection of any of these brands to be used with confidence in the dental practice. This will strengthen the collaboration between the academy and the companies, which would allow them to improve the quality of their products. Locally there are no studies available comparing the articaine-type anesthetic with epinephrine at the same concentration, manufactured locally by a national company, to a foreign one, which is an important opportunity to expand the knowledge and create scientific reports, about what a local anesthetic is and what it does. Finally, this study would contribute to the need to guarantee the quality of medicines in Colombia, by means of compliance with the legal provisions contemplated in resolution 1890 of November 2001 and 1400 of August 2001, issued by the Ministry of Health of Colombia : "Requirements to demonstrate the therapeutic effectiveness, through studies of Bioavailability and Bioequivalence of medicines for a special group of them.

NCT ID: NCT04082598 Completed - Clinical trials for Post-Op Complication

Antibiotic Therapy in Erupted Tooth Extractions

Start date: October 1, 2016
Phase: Phase 4
Study type: Interventional

Evaluation of the efficacy of amox+clav and of a probiotic after tooth extraction. the aim is to evaluate efficacy of antibiotic therapy after tooth extractions in preventing infections as compared to no therapy, and efficacy of probiotics in preventing gastro-intestinal adverse effects during the antibiotic treatment. The number of patients to be included is 150. The study products are: Amoxicillin + Clavulanic Acid and Bifidobacterium Longum and Lactoferrin.

NCT ID: NCT04064853 Completed - Pain, Postoperative Clinical Trials

Childrens' Experiences of Pain in Conjunction With Tooth Extraction - a Grounded Theory Study

Start date: April 5, 2019
Phase:
Study type: Observational

This is a qualitative study, using Grounded Theory. The aim is to deepen our knowledge about how children perceive pain in conjunction with dental treatment; tooth extractions in particular. What increases, and what decreases, the risk of children experiencing pain; and how do they perceive dental treatments where pain might occur, either as procedural pain, or postoperatively?

NCT ID: NCT03985033 Completed - Tooth Extraction Clinical Trials

The Clinical and Biological Effects of Leucocyte and Platelet-rich Fibrin (L-PRF) on Post-extraction Sockets Healing

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

This study evaluates the clinical and biological effects of leucocyte and platelet-rich fibrin (L-PRF) on post-extraction sockets healing.

NCT ID: NCT03851289 Completed - Tooth Extraction Clinical Trials

Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

Start date: April 22, 2016
Phase: N/A
Study type: Interventional

This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.

NCT ID: NCT03786029 Completed - Tooth Extraction Clinical Trials

Pre-emptive Analgesic Administration in Primary Tooth Extraction

Start date: April 1, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Brief Summary: Aims: The objective of the current study will be to compare the effectiveness of Ibuprofen, Acetaminophen, and Placebo on reducing injection pain and post-operative pain in primary tooth extraction, and to compare the parents' satisfaction. Design: This will be a blinded, randomized placebo-controlled trial including sixty six cooperative children, aged 6-8 years old.

NCT ID: NCT03584789 Completed - Tooth Extraction Clinical Trials

De-Implementing Opioids for Dental Extractions

DIODE
Start date: February 17, 2020
Phase: N/A
Study type: Interventional

The overarching goal of this project is to de-implement the reliance on opioid analgesics and to implement reliance on non-opioid analgesics to manage postoperative pain following dental extractions. Using a prospective, provider-level, 3-arm cluster randomized trial design, the investigators will compare different strategies to reduce the reliance on opioids and increase the use of alternative pain management approaches utilizing information support tools aimed at both providers and their patients.

NCT ID: NCT03545022 Completed - Anxiety Clinical Trials

Acupuncture on Anxiety and Inflammatory Events Following Surgery of Mandibular Third Molars

Start date: August 2016
Phase: N/A
Study type: Interventional

The aim of this study was to compare the effect of acupuncture and placebo acupuncture for the control of pain, edema, and trismus following the extraction of third molars and control of preoperative anxiety. Patients who met the study criteria were randomized to the type of acupuncture (active acupuncture or placebo acupuncture) and to the side of the first surgery (right or left).

NCT ID: NCT03487718 Completed - Tooth Extraction Clinical Trials

A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study.

Start date: March 26, 2018
Phase: N/A
Study type: Interventional

This 14 weeks longitudinal study will be conducted from March 2018 to June 2020, with a 40 participants. No subjects has received placebo medication at any point in the research procedures. Null hypothesis: The use of L-PRF plug, in combination with non-resorbable, open barrier membrane technique to fill the extraction sockets will have no effect on the quality of the newly formed bone nor on the dimensional changes of the ridge, compared to non-resorbable, open barrier membrane technique with natural blood clot.

NCT ID: NCT03464786 Completed - Tooth Extraction Clinical Trials

A Clinical Study on the Efficacy and Safety of Lando® Absorbable Collagen Membrane in Oral Bone Repair

Start date: April 3, 2018
Phase: N/A
Study type: Interventional

This is a randomized, paralleled, control trial to validate the effectiveness and safety of Lando® absorbable collagen membrane for oral bone repair.