Clinical Trials Logo
  1. Home
  2. Tooth Extraction
  3. NCT03985033

The Clinical and Biological Effects of Leucocyte and Platelet-rich Fibrin (L-PRF) on Post-extraction Sockets Healing

Tooth Extraction Clinical Trial

Official title:
The Clinical and Biological Effects of Leucocyte and Platelet-rich Fibrin (L-PRF) on Post-extraction Sockets Healing: a Randomized Controlled Trial

Clinical Trial Summary

This study evaluates the clinical and biological effects of leucocyte and platelet-rich fibrin (L-PRF) on post-extraction sockets healing.

Clinical Trial Description

Tooth extraction is one of the most frequent dental surgical procedures. Following tooth extraction, dimensional changes of the alveolus are inevitable, which consequently decrease the height and width of alveolar bone and impair ideal implant placement and conventional prosthetic treatment. In order to reduce the bone resorption after tooth extraction, the use of platelet concentrates has been proposed. Platelet rich fibrin (PRF) is a second generation of platelet concentrates consisting of platelets, leukocyte and growth factors harvested from blood. PRF not only supports hemostasis but also favors the natural wound healing process. Over the past decade, PRF has gained tremendous momentum having been utilized for a variety of dental and medical procedures including the management of post-extraction sockets. To date, several studies have assessed the efficacy of the use of PRF in promoting postextraction sockets healing. However, results remain contradictory and mainly focus on the clinical and radiological hard and soft tissue healing, aesthetics and postoperative discomfort. The mechanistic hypothesis is that growth factors released by PRF preparations modulate the wound healing process but the effect of local PRF application on the kinetics of release of wound healing modulators has not been studied so far. There is also a lack of information in the literature regarding the biological evaluation during postextraction sockets healing to understand the potential mechanisms. In order to assess the presence or follow dynamics of biomarkers, in this study wound fluid (WF) will be collected from the post-extraction sockets and utilized for multiplex immunoassay. Multiplex immunoassay allows simultaneous quantification of multiple markers providing unique information for a more complete understanding of the potential mechanism of PRF and spontaneous extraction socket healing. Therefore, the aim of this randomized clinical trial is to evaluate the effects of PRF on biomarkers response during post-extraction sockets healing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03985033
Study type Interventional
Source The European Research Group on Periodontology (ERGOPerio)
Contact
Status Completed
Phase N/A
Start date October 1, 2019
Completion date December 31, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT04166890 - Comparison of the Efficacy and Safety of Two Homologous Active Principles for Local Dental Anesthesia Phase 4
Active, not recruiting NCT02952209 - The Effect of Alveolar Ridge Preservation After Tooth Extraction in the Posterior Maxilla N/A
Completed NCT02155764 - Ridge Preservation With New Class of Osteoplastic Materials Phase 2
Completed NCT01588444 - Ridge Preservation After Tooth Extraction Using Cortical Versus Cancellous Freeze Dried Bone Allograft N/A
Completed NCT00387140 - A Study to Evaluate the Safety and Efficacy of an Investigational Drug in the Treatment of Postoperative Dental Pain (MK-2295-005) Phase 2
Recruiting NCT06245161 - Efficacy of Computer Controlled Intraosseous Anesthesia in Pediatric Dental Patients N/A
Recruiting NCT05615272 - Treatment of Alveolar Osteitis: Traditional or Regenerative? N/A
Completed NCT05101954 - Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants N/A
Completed NCT04082598 - Antibiotic Therapy in Erupted Tooth Extractions Phase 4
Completed NCT01924390 - Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft N/A
Completed NCT04930497 - Vestibular Socket Therapy With and Without Bone Grafting N/A
Completed NCT03191448 - Ridge Preservation Using FDBA and a Collagen Wound Dressing in Molar Sites N/A
Completed NCT03211312 - Prediction Model of Cardiac Risk for Dental Extraction in Elderly Patients With Cardiovascular Diseases
Not yet recruiting NCT06038695 - Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB N/A
Completed NCT05845437 - On Adequacy of Referrals to Oral and Maxillofacial Surgery
Recruiting NCT05220462 - Remimazolam vs Midazolam Cognitive and Motor Recovery After Intravenous Conscious Sedation for Dental Extractions. Phase 3
Active, not recruiting NCT03943680 - Plasma Rich in Growth Factors in Post-extraction Sockets N/A
Recruiting NCT05106855 - Comparative Study of Immediate Single Unit Implants in Early Loading Protocols, With or Without Photobiomodulation. N/A
Completed NCT03487718 - A 14 Weeks Longitudinal Study to Investigate the Effect of Leukocyte- Platelet Rich Fibrin Plug on the Quality of the Newly Formed Bone in Ridge Preservation Procedure Following a Tooth Extraction. It is a Clinical, Radiographic and Histomorphometric Study. N/A
Active, not recruiting NCT04705181 - The Indications of First Molar Extraction at Tufts University, School of Dental Medicine