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Syndrome clinical trials

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NCT ID: NCT05022303 Terminated - Covid19 Clinical Trials

AT1001 for the Treatment of COVID-19 Related MIS-C

Start date: October 1, 2021
Phase: Phase 2
Study type: Interventional

The primary aim of this study is to evaluate the efficacy and safety of AT1001 versus placebo in pediatric patients with SARS-CoV-2 infection who experience early signs of MIS-C and are at high risk of progression. AT1001 10 μg/kg/dose up to 500 μg/dose (rounded to the nearest 50 μg) or matching placebo will be administered orally four times a day (QID) to the standard of care for MIS-C.

NCT ID: NCT05006417 Terminated - Clinical trials for Compartment Syndrome of Leg

Botox for the Treatment of Recurrent Chronic Exertional Compartment Syndrome

Start date: November 23, 2022
Phase: Phase 4
Study type: Interventional

10 participants with Recurrent Chronic Exertional Compartment Syndrome (R-CECS) will be enrolled in a 6 month study at the University of Wisconsin Hospitals and Clinics to test the hypothesis that injection of Botox into the affected muscle group will alleviate pain associated with R-CECS.

NCT ID: NCT04991688 Terminated - Clinical trials for Refractory Medical Treatment After Rectal Resection

A Prospective Pilot Study to Assess the Efficacy of BOTOX-A in Patients With Low Anterior Resection Syndrome (LARS>20) and Refractory Medical Treatment After Rectal Resection

BOTOX-TME
Start date: September 1, 2021
Phase: Phase 2
Study type: Interventional

After rectal resection for cancer (with or without stoma), patients may have digestive sequelae. LARS (Low Anterior Resection Syndrome) includes bowel frequency, stool fragmentation, urgency, and faecal incontinence. The goal of this study is to test intra-rectal BOTOX-A on functional outcomes and quality of life of patients with LARS refractory to medical treatment at 3 months after surgery.

NCT ID: NCT04988997 Terminated - Clinical trials for Short Bowel Syndrome

VIBRANT Study of Vurolenatide in Adult Patients With Short Bowel Syndrome.

Start date: June 14, 2021
Phase: Phase 2
Study type: Interventional

A Study of Vurolenatide in Adult Patients with Short Bowel Syndrome.

NCT ID: NCT04988087 Terminated - Sjogren Syndrome Clinical Trials

A Study to Evaluate the Safety, Tolerability and Efficacy of MHV370 in Participants With Sjogren's Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD)

Start date: November 30, 2021
Phase: Phase 2
Study type: Interventional

This study is a basket trial designed to establish safety, tolerability and efficacy of MHV370 in Sjögren's Syndrome (SjS) and Mixed Connective Tissue Disease (MCTD).

NCT ID: NCT04978779 Terminated - Clinical trials for Chronic Lymphocytic Leukemia

A Study to Evaluate VIP152 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia or Richter Syndrome

Start date: December 16, 2021
Phase: Phase 1
Study type: Interventional

Determine the safety, tolerability, pharmacokinetics, maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of VIP152 as monotherapy or in combination with a BTKi in patients with Chronic Lymphocytic Leukemia (CLL) or Richter Syndrome

NCT ID: NCT04977492 Terminated - Clinical trials for Excessive Lateral Pressure Syndrome

Retrospective Clinical Study of Excessive Lateral Pressure Syndrome

Start date: January 1, 2015
Phase:
Study type: Observational

This research focuses on 1 January 2015 to December 2018 to the undergraduate course to see a doctor and accept the lateral retinaculum extracapsular release of 100 patients were retrospectively study, through the follow-up, compare the preoperative and postoperative radiographic data, clinical manifestations, signs, etc., to evaluate the surgical effect and explore the pathogenesis of patellar lateral compression syndrome.

NCT ID: NCT04972318 Terminated - Clinical trials for Acute Respiratory Distress Syndrome

Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia

STAMINA
Start date: September 4, 2021
Phase: N/A
Study type: Interventional

Randomized Controlled Trial Comparing Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia. The control strategy will be based on ARDSNet approach. The intervention group will receive a different ventilatory strategy based on positive end-expiratory pressure tailored according to compliance and limited driving pressure.

NCT ID: NCT04969991 Terminated - Clinical trials for Coronavirus Disease 2019

Study of Varespladib in Patients Hospitalized With Severe COVID-19

STAIRS
Start date: June 30, 2021
Phase: Phase 2
Study type: Interventional

This is a 2-part, multi-center, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability, and efficacy of oral varespladib, in addition to standard of care, in patients hospitalized with severe COVID-19 caused by SARS-CoV-2.

NCT ID: NCT04936451 Terminated - Breast Cancer Clinical Trials

Electrotherapy in the Management of Myofascial Syndrome

MODYMYO
Start date: January 5, 2022
Phase: N/A
Study type: Interventional

Myofascial syndrome is defined as "musculoskeletal pain characterized by local and referred pain perceived to be deep and constant, and by the presence of myofascial trigger points in any part of the body" Post-breast surgery myofascial syndrome affects up to 44.7% of operated women, mainly on the muscles of the greater shoulder girdle. The repercussions are significant, functional, somatic, psychological and socio-professional affecting the quality of life. The treatments offered may or may not be medicinal. Transcutaneous electrical nerve stimulation (TENS) is a therapy that uses low voltage electrical current to provide pain relief. A TENS unit consists of a battery-powered device that delivers electrical impulses through electrodes placed on the surface of your skin. The electrodes are placed at or near nerves where the pain is located or at trigger points.