Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Surgery Clinical Trial

— PronMed  

Official title:

Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03720860
• Other study ID #: 2017-043PronMed
• Status: Recruiting
• Start date: January 1, 2018
• Est. completion date: May 2026

Study information

• Verified date: May 2024
• Source: Uppsala University
• Contact: Sara Bulow, MD
• Phone: +46730247414
• Email: sara.bulow.anderberg[@]akademiska.se
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: May 2026
• Est. primary completion date: May 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Patients admitted to the intensive/post operative care unit

• with septic shock or

• post major surgery or

• after intoxication with a chemical compund

Exclusion Criteria:

• Pregnancy or

• Breast feeding or

• Chronic kidney disease or

• intoxication with nephrotoxic compund or

• lack of informed consent

Related Conditions & MeSH terms

• Acute Kidney Injury
• Sepsis
• Surgery
• Wounds and Injuries

Locations

Country	Name	City	State
Sweden	Akademiska sjukhuset, Centraloperation	Uppsala

Sponsors (2)

Lead Sponsor	Collaborator
Uppsala University	Maastricht University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Histones	Correlation between levels of histones and degree of acute kidney injury	Within 1 month
Secondary	Other inflammtory mediators	Correlation between levels of other inflammtory mediators and degree of acute kidney injury	Within 1 month