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NCT03720860 Clinical Trial

Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Surgery Clinical Trial

— PronMed  

Official title:
Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03720860
Other study ID # 2017-043PronMed
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 1, 2018
Est. completion date May 2026

Study information
Verified date May 2024
Source Uppsala University
Contact Sara Bulow, MD
Phone +46730247414
Email sara.bulow.anderberg@akademiska.se
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date May 2026
Est. primary completion date May 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Patients admitted to the intensive/post operative care unit - with septic shock or - post major surgery or - after intoxication with a chemical compund Exclusion Criteria: - Pregnancy or - Breast feeding or - Chronic kidney disease or - intoxication with nephrotoxic compund or - lack of informed consent

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Sweden Akademiska sjukhuset, Centraloperation Uppsala

Sponsors (2)
Lead Sponsor Collaborator
Uppsala University Maastricht University

Country where clinical trial is conducted

Sweden, 

Outcome
Type Measure Description Time frame Safety issue
Primary Histones Correlation between levels of histones and degree of acute kidney injury Within 1 month
Secondary Other inflammtory mediators Correlation between levels of other inflammtory mediators and degree of acute kidney injury Within 1 month
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