Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Evaluation of acoustic changes in the speech signal before and after each rehabilitation protocol |
Assessment of acoustic properties (formants, voice onset time and spectral moments) with a phoneme repetition task. Repeated phonemes are isolated vowels, semi-consonants in vowel context and consonants in /a/ context with the consonants (C) placed in initial (/Ca/) or medial (/aCa/) positions. |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in inner speech abilities before and after each rehabilitation protocol - Inner speech testing 1 |
Evaluate inner speech abilities with an introspective questionnaire |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in inner speech abilities before and after each rehabilitation protocol - Inner speech testing 2 |
Evaluate inner speech abilities with a behavioral task (homophone detection task) |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Clinical language assessment 1a |
Assessment of oral and written expression with BDAE (Boston Diagnostic Aphasia Examination). |
Baseline pre-intervention |
|
Secondary |
Evaluation of changes in language abilities before and after rehabilitation - Clinical language assessment 1b |
Assessment of oral expression (picture naming) with BDAE (Boston Diagnostic Aphasia Examination). |
Immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Clinical language assessment 2a |
Assessment of transcoding (word/sentence repetition and syllable/word reading) with BDAE (Boston Diagnostic Aphasia Examination). |
Baseline pre-intervention |
|
Secondary |
Evaluation of changes in language abilities before and after rehabilitation - Clinical language assessment 2b |
Assessment of transcoding (word repetition and word reading) with BDAE (Boston Diagnostic Aphasia Examination). |
Immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in language abilities before and after each rehabilitation protocol - Clinical language assessment 3 |
Assessment of verbal fluency with phonemic and semantic fluency tasks. The patient must generate words that satisfy certain criteria: beginning with a particular letter (phonemic fluency) or belonging to a particular semantic category (semantic fluency). |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Clinical language assessment 4 |
Assessment of bucco-facial praxia with MT-86 (Montreal-Toulouse aphasia language examination protocol). |
Baseline pre-intervention |
|
Secondary |
Evaluation of changes in language abilities before and after each rehabilitation protocol - Clinical language assessment 5 |
Assessment of phonemic discrimination with BALE (Batterie Analytique du Langage Ecrit). |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in language abilities before and after each rehabilitation protocol - Clinical language assessment 6 |
Assessment of phonological awareness with a rhyme detection task. The patient must decide whether two heard words rhyme or not. |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in cognitive level before and after each rehabilitation protocol - Neuropsychological assessment 1 |
Assessment of general cognitive level with CASP (Cognitive Assessment Scale for Stroke Patients). CASP evaluates several abilities (naming, comprehension, inhibition, flexibility etc.) and the global score is out of 36. |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in specific executive functions before and after each rehabilitation protocol - Neuropsychological assessment 2 |
Assessment of visuo-spatial span with the Corsi blocks task. |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in specific executive functions before and after each rehabilitation protocol - Neuropsychological assessment 3 |
Assessment of non-verbal fluency with the Ruff figural fluency test. |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in specific executive functions before and after each rehabilitation protocol - Neuropsychological assessment 4 |
Assessment of executive functions with the TMT A-B (Trail Making Test A-B). |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in non-verbal episodic memory before and after each rehabilitation protocol - Neuropsychological assessment 5 |
Assessment of non-verbal episodic memory with BEM84 (Batterie d'Efficience Mnésique de Signoret). This test contains an immediate recall task (score out of 12) and a delayed recall task (score out of 12). |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of changes in mental rotation abilities before and after each rehabilitation protocol - Neuropsychological assessment 6 |
Assessment of mental rotation abilities. |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of mood changes before and after each rehabilitation protocol - Neuropsychological assessment 7 |
Assessment of depression with Aphasic Depression Rating Scale (ADRS; score out of 32; a score lower than 7 is for "no depression"). |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Evaluation of mood changes before and after each rehabilitation protocol - Neuropsychological assessment 8 |
Assessment of anxiety with Hamilton scale (score out of 56; a score lower or equal to 12 is for "normal anxiety"; a score between 12 and 20 is for "mild anxiety"; a score between 20 and 25 is for "moderate anxiety"; a score higher than 25 is for "severe anxiety"). |
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention |
|
Secondary |
Neuropsychological assessment 9 |
Assessment of familiarity degree with digital tools with an in-house test developed by the neuropsychologists from our clinical setting. This task allows to evaluate the use of the computer tools, its frequency of use and the type of activities carried out. |
Baseline pre-intervention |
|
Secondary |
Evaluation of brain network activation (with measurement of BOLD, Blood Oxygen Level Dependent) before and after rehabilitation - Evaluation-brain 1 |
Assessment of brain networks modulation with fMRI (functional MRI) tasks : word repetition (repeating a heard word), picture-prompted rhyme detection (judging if verbal labels of pictures presented in pairs rhyme or not), auditory rhyme detection (decide whether two heard words rhyme of not), picture naming (naming pictures) and word reading (reading visually presented words). |
Baseline pre-intervention; immediately after the first intervention |
|
Secondary |
Evaluation of brain functional connectivity before and after rehabilitation - Evaluation-brain 2 |
Assessment of functional connectivity with rs-fMRI (resting state-functional MRI). |
Baseline pre-intervention; immediately after the first intervention |
|
Secondary |
Evaluation of brain anatomical connectivity before and after rehabilitation - Evaluation-brain 3 |
Assessment of diffuse white-matter changes in multiple bundles with MRI-DTI (Diffusion Tension Imaging). |
Baseline pre-intervention; immediately after the first intervention |
|