Stroke Clinical Trial
Official title:
Evolution of Ischemic Stroke Subtypes in Hong Kong
Verified date | June 2020 |
Source | Chinese University of Hong Kong |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Stroke is the 4th leading cause of mortality in Hong Kong. It also carries considerable
socioeconomical consequences due to disability.
Ischemic stroke can be classified by the TOAST classification, which includes large artery
atherosclerosis, cardioembolism, small-artery occlusion and other causes (1). Among which,
intracranial atherosclerosis (ICAS) had been major cause of acute ischemic stroke (AIS) in
the Asia Pacific. It was estimated as high as 24.1% of AIS or transient ischemic attacks
(TIAs) were attributed to ICAS in China (2). Management of ICAS related strokes has been
challenging owing to its high rate of recurrence despite medical therapy. Recent randomized
clinical trial suggested that aggressive medical therapy may result in reduction in
recurrence compared with historical cohorts (3).
Our group has previously observed a 2.5-fold increase in atrial fibrillation related stroke
over a 15-year period (4). The inverstigator also observed a decline in ICAS related AIS as
well as its recurrent stroke risk throughout the recent years. Possible mechanisms include
better management of metabolic risk factors and aggressive secondary prevention. Other
possible reasons are increased atrial fibrillation (AF), small vessel disease (SVD) or other
stroke mechanisms.
This study is aim to find the evolution of different stroke subtypes in relation to the
characteristics of our stroke population over a 15-year period. This may influence
territorial prevention strategy.
Status | Completed |
Enrollment | 10000 |
Est. completion date | October 31, 2019 |
Est. primary completion date | October 31, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - All consecutive Chinese stroke patients included in the Prince of Wales Hospital stroke registry at 2-year intervals, i.e. from 2004 to 2018 Exclusion Criteria: 1. Uncertain diagnosis of stroke 2. Non-Chinese patients |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Chinese University of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of ischemic stroke subtype in Hong Kong with the advancement of primary care of cardiovascular control. | Stroke subtypes of the patients in the past 15 years will be classified by the reference of TOAST classification. | 31 Jul, 2019 | |
Secondary | The changes of stroke etiology in the population over 15-year period in Hong Kong | Stroke etiology will be determined by the imaging including carotid duplex, transcranial doppler, computer tomography (CT), CT angiogram, magnetic resonance imaging (MRI), MR angiogram, electrocardiography (ECG) and echocardiography. | 31 Dec, 2019 |
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