Stroke Clinical Trial
Official title:
Respiratory Virus Infections in Acutely Hospitalized Adult Patients With Pulmonary and Extrapulmonary Complications
Respiratory virus infections are one of the major causes of hospitalizations, and outbreaks
of respiratory virus infection have led to severe economic loss. In addition to pulmonary
complications, respiratory viruses can also lead to non-pulmonary complications.
However, many previous studies on the complications of respiratory viruses are retrospective
in nature, and therefore many patients with respiratory virus infection may not be tested.
Furthermore, these studies did not take into account that respiratory viruses can be found in
some asymptomatic individuals. The aim of this study is to capture the burden of respiratory
viruses in patients with acute pulmonary and extrapulmonary complications. We will recruit
patients admitted to our hospital with acute coronary syndrome, stroke and exacerbation of
underlying lung diseases. We will collect saliva from these patients and test for respiratory
viruses. As controls, we will recruit asymptomatic patients at the out-patient clinic for
follow up of chronic heart, lung or neurological diseases.
We anticipate that this study will greatly enhance our understanding of the epidemiology of
respiratory viruses in acutely hospitalized patients. Our findings will be important for
clinicians, public health practitioners and scientists.
Respiratory viruses cause severe infections, and contribute to a substantial number of
hospitalizations, admission to intensive care units and deaths. Many hospitalizations due to
respiratory virus infection are related to pneumonia or exacerbation of chronic lung disease.
In addition, many hospitalizations are related to extrapulmonary complications, such as acute
coronary syndrome or stroke.
Previous studies have reported the incidence of respiratory viruses among patients with
pulmonary complications, or the association of respiratory viruses with acute coronary
syndrome or stroke. However, there are several problems associated with these studies. First,
many of these studies are retrospective in nature, and therefore testing was only performed
in selected patients with respiratory symptoms. Hence, many patients without respiratory
symptoms were not recruited. Second, respiratory virus can be detected in some asymptomatic
individuals. Therefore, the presence of respiratory virus may be an incidental finding rather
than the cause of the complication. Third, many studies only focus on a few respiratory
viruses, especially on influenza virus.
This study aims to address these issues. The investigators propose to conduct a prospective
cohort study. The investigators will recruit hospitalized adult patients with exacerbation of
underlying lung disease, acute coronary syndrome or stroke. As controls, the investigators
will recruit outpatients follow-up for chronic heart disease, chronic lung disease or
neurological conditions. The investigators will collect saliva from study participants and
perform respiratory virus testing using a multiplex PCR panel. Previous studies have shown
that there is a high concordance between results from respiratory virus testing on saliva and
nasopharyngeal specimens. The investigators will also use a standardized questionnaire to
collect information regarding symptoms.
This study will provide accurate data on the epidemiology of respiratory viruses in pulmonary
and extrapulmonary complications.These data are important for clinicians, public health
practitioners and scientists.
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