Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients

Stroke Clinical Trial

— COCON  

Official title:

Impact of Muscular Fatigability on Spastic Co-contractions Between the Quadriceps and Hamstrings in Stroke Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03342820
• Other study ID #: 2016_50
• Secondary ID: 2017_A01605-48
• Status: Completed
• Phase: N/A
• Start date: January 19, 2018
• Est. completion date: October 10, 2019

Study information

• Verified date: March 2020
• Source: University Hospital, Lille
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the effects of an isokinetic fatigue protocol of the quadriceps on the amount of co-contractions of this last with the hamstrings during a maximal isometric flexion movement in hemiparetic stroke patients.

The effect of such a protocol on gait parameters and spasticity of the quadriceps will be evaluated also.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: October 10, 2019
• Est. primary completion date: October 10, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Age between 18 and 80y

• Hemiparesis after a first-ever stroke > 3 months

• Spasticity of the quadriceps muscle

• Quadriceps strength at least at 3/5 (MRC testing)

• Subject able to walk at least 2min without rest

• Informed consent

• Social security affiliation

Exclusion Criteria:

• Severe comprehension troubles (language, cognitive or psychiatric disorders)

• History of previous stroke, locomotor or other neurological disorders

• Locomotor troubles affecting the paretic arm

• Contraindication to efforts : cardiac insufficiency, severe aortic valvular stenosis, recent heart failure, non treated high blood pressure, severe peripheral arterial disease

• Pregnancy or breastfeeding

• Adult subject to guardianship

Related Conditions & MeSH terms

• Fatigue
• Gait Disorders, Neurologic
• Gait, Hemiplegic
• Muscle Fatigue
• Muscle Spasticity
• Spasticity, Muscle
• Stroke

Intervention

Procedure:
• Muscle fatigue
Isokinetic quadriceps muscle fatigue of the paretic lower limb

Locations

Country	Name	City	State
France	Hôpital Swynghedauw, CHU	Lille

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cocontraction Index (CCI) between the rectus femoris and the semitendinosus	ratio of the RMS of a the rectus femoris when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG	one day
Secondary	Cocontraction Index (CCI) between the other parts of the quadriceps and the semitendinosus muscle	ratio of the RMS of a the vastus medialis, lateralis and intermedius when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG	one day
Secondary	Agonist Recruitment Index of the semitendinosus	ratio of the RMS of a muscle acting as an agonist during a given period to its largest RMS value observed during the 500 ms around its agonist recruitment peak	one day
Secondary	Isometric peak knee flexion torque	Isometric peak knee flexion torque assessed by a CONTREX dynamometer	one day
Secondary	Spasticity of the quadriceps	Tardieu scale angle	one day
Secondary	spatio-temporal gait parameters at comfortable speed	Gait speed	one day
Secondary	spatio-temporal gait parameters at comfortable speed	Gait cadence	one day
Secondary	spatio-temporal gait parameters at comfortable speed	Step length	one day
Secondary	Isometric peak knee extension torque	Isometric peak knee extension torque assessed by a CONTREX dynamometer	one day
Secondary	10 metre walk test (10MWT)	Assessment of max gait speed	one day
Secondary	2 minute walk test (2MWT)	Assessment of max walking endurance	one day
Secondary	perceived exertion at the end of the 2MWT (Borg Scale 6-20)		one day