Pupillometry in Horner's Syndrome

Stroke Clinical Trial

Official title:

Automated Pupillometry for the Diagnosis of Horner's Syndrome in Acute Stroke Patients Due to Carotid Artery Dissection

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02978079
• Other study ID #: KEK-Nr. 2016-02151
• Status: Recruiting
• Phase: N/A
• Start date: February 15, 2017
• Est. completion date: December 31, 2022

Study information

• Verified date: January 2021
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the eye. Dissection of the carotid artery is one of the etiologies for ischemic stroke in young patients. In our current study, we will explore the diagnostic accuracy of automated binocular pupillometry in the diagnosis or HS, and its potential in identifying dissection of the carotid artery in patients of young age who suffer ischemic stroke.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 135
• Est. completion date: December 31, 2022
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Adults 60 years of age or younger
• Acute stroke (less than 72 hours from admission)
• Informed Consent as documented by signature (Appendix Informed Consent Form)
• Ability to understand the study information and consent form

Exclusion Criteria:

• known history of HS
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• Medications affecting pupillary response
• History of ocular surgery affecting the pupil

Related Conditions & MeSH terms

• Dissection Carotid Artery
• Horner Syndrome
• Horner's Syndrome
• Stroke
• Syndrome

Intervention

Device:
• Automated pupillometry
Automated pupillometry will be performed in patients with acute stroke with the intention of diagnosing Horner's syndrome

Locations

Country	Name	City	State
Switzerland	Ophthalmology Department, University Hospital Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Finding of pupillary dilation lag using pupillometry in patients with acute stroke due to carotid artery dissection		1 day of initial visit