Transcranial Direct Current Stimulation for Post-Stroke Aphasia

Stroke Clinical Trial

Official title:

Enhancing Aphasia Therapy With Anodal Transcranial Direct Current Stimulation in Chronic Stroke Patients

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02461355
• Other study ID #: AAAO1700
• Status: Terminated
• Phase: N/A
• Start date: June 2015
• Est. completion date: June 2016

Study information

• Verified date: April 2019
• Source: Columbia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a randomized, crossover design trial that will compare how anodal transcranial direct current stimulation (tDCS) versus sham tDCS administered during multiple sessions of scripting therapy affects the acquisition and retention of trained scripts.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 2
• Est. completion date: June 2016
• Est. primary completion date: June 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

1. Age over 21 years

2. Ischemic left hemispheric stroke verified by imaging (CT or MRI) greater than 6 months ago

3. Residual non-fluent or anomic aphasia, with Western Aphasia Battery-Revised Aphasia Quotient score <60

4. Fluent English speaker prior to stroke

5. Right-handed prior to stroke

6. Ability to give informed consent and understand the tasks involved.

Exclusion Criteria:

1. History of recurrent stroke, either ischemic or hemorrhagic, in the left middle cerebral artery territory

2. Imaging unavailable

3. Large middle cerebral artery infarct involving entire inferior division (temporo-parietal) territory

4. History of dementia prior to the stroke

5. History of seizure, prior electroconvulsive therapy, deep brain stimulators, or brain surgery

6. Social and/or personal circumstances that interfere with ability to return for therapy and assessment sessions.

Related Conditions & MeSH terms

• Aphasia
• Stroke

Intervention

Behavioral:
• Aphasia therapy
Aphasia therapy using a computerized scripting program

Device:
• Anodal tDCS
Anodal transcranial direct current stimulation using the Chattanooga Ionto device
• Sham tDCS
Sham transcranial direct current stimulation using the Chattanooga Ionto device

Locations

Country	Name	City	State
United States	Adler Aphasia Center	Maywood	New Jersey

Sponsors (2)

Lead Sponsor	Collaborator
Columbia University	Pitkin Foundation

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in Percent Script Words Omitted		Baseline to immediate, 2 weeks, and 4 weeks post-training
Primary	Change in Percent Correct of Trained Scripts		From Baseline to up to 2 days post-training
Primary	Change in Words Per Minute of Trained Scripts		From Baseline to up to 2 days post-training
Secondary	Change in Percent Correct of Trained Scripts		Baseline to 2 weeks and 4 weeks post-training
Secondary	Change in Words Per Minute of Trained Scripts		Baseline to 2 weeks and 4 weeks post-training