Stroke Clinical Trial
Official title:
Critical Periods After Stroke Study (CPASS); Sensitive Periods and Consumer Preferences: Optimizing Upper Extremity Stroke Rehabilitation
To perform an exploratory single center randomized study that will form the basis for a
larger scale, more definitive randomized clinical trial to determine the optimal time after
stroke for intensive motor training. The investigators will perform a prospective exploratory
study of upper extremity (UE) motor training delivered at higher than usual intensity at
three different time points after stroke:
- early (initiated within 30 days)
- subacute/outpatient (initiated within 2-3 months)
- chronic (initiated within 6-9 months)
The control group will not receive the therapy intervention during the 1-year study.
Outcome measures will be assessed at baseline, pre-treatment, post-treatment, 6 months and
one year after stroke onset.
Compared to individuals randomized during the outpatient (2-3 months after stroke onset) or
chronic (6-9 months after stroke onset) time points, participants randomized to early
intensive motor training will show greater upper extremity motor improvement measured at one
year post stroke.
Please see the following reference:
Dromerick, A.W., Edwardson, M., Edwards, D.F., Giannetti, M.L., Barth, J., Brady, K.P., Chan,
E., Tan, M.T., Tamboli, I., Chia, R., Orquiza, M., Padilla, R.M., Cheema, A.K., Mapstone, M.,
Fiandaca, M.S., Federoff, H.J., & Newport, E.L. (2015). Critical Periods after Stroke Study:
Translating animal stroke recovery experiments into a clinical trial. Frontiers in Human
Neuroscience, 9, 002231. PMCID: PMC4413691.
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