Speech Therapy for Aphasia: Comparing Two Treatments

Stroke Clinical Trial

— PMvSFA  

Official title:

A Prospective, Controlled Study of Rehabilitation of Anomia in Aphasia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02153710
• Other study ID #: O1183-R
• Status: Completed
• Phase: N/A
• Start date: March 11, 2014
• Est. completion date: September 29, 2017

Study information

• Verified date: July 2019
• Source: VA Office of Research and Development
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a behavioral speech therapy trial for individuals who have suffered a stroke on the left side of the brain and have difficulty speaking. The name of this disorder is called "aphasia." Individuals in this study will receive one of two treatments. The first is a phonological (sound level) treatment and the second is a semantic (word level) treatment. Individuals in both groups will receive 60 hours of therapy for free (2 hours/day, 5 days/week, 6 weeks).

Description:

Purpose: The ultimate goal of anomia treatment should be to achieve gains in exemplars trained in the therapy session as well as generalization to untrained exemplars and contexts. Phonomotor treatment (PMT) has shown such effects but has not yet been compared to a commonly used lexical/semantic based treatment (semantic feature analysis; SFA).

Methods: In a between group randomized controlled trial, 58 persons with aphasia characterized by anomia and phonological dysfunction were randomized to receive 56-60 hours of intensively delivered treatment over 6 weeks with testing pre-, post- and three-months post treatment termination.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 58
• Est. completion date: September 29, 2017
• Est. primary completion date: August 21, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Single, left-hemisphere stroke

• English as primary language prior to stroke

Exclusion Criteria:

• Other neurological disorders

• Untreated depression

Related Conditions & MeSH terms

• Aphasia
• Stroke

Intervention

Behavioral:
• Semantic Feature Analysis therapy
Control therapy; current standard of care therapy
• Phonomotor Therapy
Experimental therapy.

Locations

Country	Name	City	State
United States	VA Puget Sound Health Care System Seattle Division, Seattle, WA	Seattle	Washington

Sponsors (3)

Lead Sponsor	Collaborator
VA Office of Research and Development	Portland State University, University of Washington

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Spoken Word Production (Confrontation Naming)	Reporting a change in percent correct scores pre-treatment versus 3-months post treatment. (0-100% scale)	Pretreatment to 3 months following treatment termination change
Secondary	Response Latency	Change in response latency of confrontation naming pre-treatment versus 3 months post treatment.	Pretreatment to 3 months following treatment termination change
Secondary	Verbs Correctly Named	Change in confrontation naming of verbs were scored for accuracy and percent correct (0% to 100%) was analyzed before versus 3 months post treatment.	Pretreatment to 3 months following treatment termination change