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Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes

Stroke Clinical Trial

Official title:
Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes

Clinical Trial Summary

This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks.

Clinical Trial Description

The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated across up to 18 adults with post-stroke phonological alexia. The short-term goals of this research proposal includes the following: 1) determine if a modified multimodal treatment of phonological alexia can improve pseudoword reading skills (providing a basis from which training will also treat real word reading skills), 2) determine if a modified multimodal treatment of phonological alexia can improve real word reading skills, 3) determine how brain lesion extent and location relate to participants' response to treatment, and 4) identify relationships between changes in functional brain activity in specified regions of interest and participants' response to treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00827268
Study type Interventional
Source VA Office of Research and Development
Contact
Status Completed
Phase N/A
Start date June 2009
Completion date July 2012
View Details
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