Comparison Between TOF and SWAN Sequences in the Detection of Arterial Occlusion in Acute Ischemic Stroke Using MRI

Stroke, Acute Clinical Trial

— TOF-SWAN  

Official title:

Comparison Between Enhanced Susceptibility-weighted Angiography and Time of Flight Sequences in the Detection of Arterial Occlusion in Acute Ischemic Stroke Using MRI

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03645902
• Other study ID #: TOF-SWAN
• Status: Completed
• Start date: March 1, 2014
• Est. completion date: December 31, 2014

Study information

• Verified date: August 2018
• Source: Lille Catholic University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Optimizing the MRI protocol in acute ischemic stroke remains a challenging issue. In this field, susceptibility-weighted sequences have proved their superiority over T2. Besides the strengthened susceptibility effect, enhanced susceptibility-weighted angiography (eSWAN) sequence provides also a time-of-flight (TOF) effect, allowing the exploration of the intracranial arterial circulation. The objective of this study is to compare eSWAN and 3D TOF, considered as the reference, in the detection of arterial occlusion in acute stroke.

Description:

Patients who undergo MRI for suspected acute stroke with an acute ischemic lesion on diffusion-weighted imaging (DWI) will be prospectively included in this study.eSWAN and TOF images will be analyzed under double-blind conditions by a junior radiologist and a senior neuroradiologist for the detection of arterial occlusion. eSWAN images will be assessed in order to estimate the inter-observer agreement. After a consensus, eSWAN and TOF data will be compared to calculate inter-modality agreement.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: December 31, 2014
• Est. primary completion date: July 31, 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• clinical symptoms compatible with acute stroke;

• time range between symptoms and magnetic resonance imaging less than 4 h 30

• presence of at least one acute ischemic lesion on the diffusion-weighted images (DWI).

Exclusion Criteria:

• MR contraindications;

• negative DWI;

• differential diagnosis;

• incomplete acquisition of the full magnetic resonance imaging protocol or technical issues leading to uninterpretable eSWAN and/or TOF sequences (e.g.motion artifacts).

Related Conditions & MeSH terms

• Angiography
• Arterial Occlusive Diseases
• Diagnosis
• Magnetic Resonance Imaging
• Stroke
• Stroke, Acute

Intervention

Diagnostic Test:
• Magnetic resonance imaging

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Lille Catholic University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concordance of observed agreement using eSWAN and TOF images measured by Cohen's kappa coefficient	Concordance of observed agreement for the detection of arterial occlusion between eSWAN and TOF images	at inclusion
Secondary	Concordance inter-observer agreement for the detection of arterial occlusion using eSWAN images measured by Cohen's kappa coefficient	Concordance inter-observer agreement between the two readers for the detection of arterial occlusion using eSWAN images	at inclusion