Manipulation of Arterial Pressure in Acute Ischemic Stroke — MAPAS  

Stroke, Acute Clinical Trial

Official title: Manipulation of Arterial Pressure Early in Non Thrombolysed Acute Ischemic Stroke: Effects on Death and Neurological Disability

Status Recruiting

Clinical Trial Summary

This is a controlled clinical trial among non thrombolysed acute ischemic stroke patients to determine the effects of three levels of arterial pressure on death and neurological disability. After the admission in the vascular unit of the Emergency Department the patients are randomized to maintain during the first 24h the Systolic Arterial Pressure in tree levels of pressure: 140 to 160 mmHg; 161 to 180 mmHg and 181 to 200 mmHg. The end point of the study is the Modified Rankin score and mortality in three month after the discharge.

Clinical Trial Description

To maintain the tree levels of systolic arterial pressure during de first 24h we will use one of the two strategies:1) infusion of 500 to 1000ml of saline solution and/or norepinephrine solution to increase de systolic pressure or 2) infusion of esmolol or nitroprussiate solution to decrease de pressure. Every patient will have a transcranial doppler study in the first 24h to measure the mean velocity of cerebral arteries. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Stroke
• Stroke, Acute

• NCT number: NCT00848770
• Study type: Interventional
• Source: Hospital de Clinicas de Porto Alegre
• Contact: Luiz A Nasi, Physician
• Phone: 55 51 9982 18 44
• Email: lnasi@terra.com.br
• Status: Recruiting
• Phase: N/A
• Start date: January 2008
• Completion date: December 2010