Stress Clinical Trial
Official title:
EEG Markers of Training-Induced Improvements in Cognitive Functioning
Verified date | March 2020 |
Source | VA Office of Research and Development |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Some of the most common, persistent, and disabling consequences of traumatic brain injury affect an individual's ability to achieve personal goals. Interventions that strengthen abilities such as being able to concentrate, remember, stay calm and overcome challenges, could have far reaching benefits for Veterans. One challenge in rehabilitation is that response to training can be highly variable, and a better understanding of the neural bases for this variability could inform care. This pilot project will test the clinical behavioral effects of a cognitive skill training intervention and explore to what extent changes in markers of the brain's electrical activity (using the non-invasive technique of electroencephalograms, EEG) can explain differences in responses to skill training.
Status | Completed |
Enrollment | 18 |
Est. completion date | June 1, 2019 |
Est. primary completion date | March 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 21 Years to 55 Years |
Eligibility |
Inclusion Criteria: - Veterans - History of TBI (as defined by the American Congress of Rehabilitation Medicine and VA, with reported plausible mechanism of head injury, loss of consciousness with some period of posttraumatic alteration in cognition), in the chronic, stable phase of recovery (>6 months from injury) - On stable psychoactive medications (> 30 days) - Able and willing to participate in EEG, training and, assessments Exclusion Criteria: - Severely apathetic/abulic, aphasic, or other reasons for being unable or unwilling to participate with the training tasks - Severe cognitive dysfunction - History of neurodevelopmental abnormalities - Ongoing illicit drug or alcohol abuse - Schizophrenia - Bipolar disorder - History of other neurological disorders - Current medical illnesses that may alter mental status or disrupt participation in the study - Active psychotropic medication changes - There will be no restriction in regard to gender, race, and socioeconomic status |
Country | Name | City | State |
---|---|---|---|
United States | VA Northern California Health Care System, Mather, CA | Sacramento | California |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development | VA Northern California Health Care System |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery | The investigators created a composite score based upon standardized performance on the following neurocognitive measures of attention and executive functions: Wechsler Adult Intelligence Test - 4th Edition- letter number sequence; Auditory Consonant Trigrams - 9, 18, 36 second conditions; Digit Vigilance Test - Total Errors; Delis-Kaplan Executive Function System Color-Word Interference Trials 3 and 4 - Time and Total Errors; & Trails B - Time. Performance on each measure was scored using populations norms, and these scores are then standardized (Z-scored) and averaged to create a composite outcome (the unit measure being Z-score). A Z-score reflects the number of standard deviations a given score is away from the population mean: A Z-score of 0 is equal to the population mean, with positive and negative values reflecting performances above and below the population mean, respectively. |
Week 1, before intervention period (baseline) | |
Primary | Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery | The investigators created a composite score based upon standardized performance on the following neurocognitive measures of attention and executive functions: Wechsler Adult Intelligence Test - 4th Edition- letter number sequence; Auditory Consonant Trigrams - 9, 18, 36 second conditions; Digit Vigilance Test - Total Errors; Delis-Kaplan Executive Function System Color-Word Interference Trials 3 and 4 - Time and Total Errors; & Trails B - Time. Performance on each measure was scored using populations norms, and these scores are then standardized (Z-scored) and averaged to create a composite outcome (the unit measure being Z-score). A Z-score reflects the number of standard deviations a given score is away from the population mean: A Z-score of 0 is equal to the population mean, with positive and negative values reflecting performances above and below the population mean, respectively. Change will be analyzed for this data as change from before to after the intervention period. |
Week 8, after the intervention period | |
Secondary | Change in Event-Related Potential (ERP) Related to Memory Retrieval (Measured in uV) | Electroencephalography (EEG) will be collected during tasks that require attention and working memory. The old/new ERP effect (difference between brain responses to correctly remembered studied items vs. correctly rejected unstudied items) will be analyzed for this data as change from before to after the intervention period. | Week 8, after the intervention period | |
Secondary | Event-Related Potential (ERP) Related to Memory Retrieval (Measured in uV) | Electroencephalography (EEG) will be collected during tasks that require attention and working memory. The old/new ERP effect (difference between brain responses to correctly remembered studied items vs. correctly rejected unstudied items) will be analyzed for this data prior to the intervention period. | Week 1, before the intervention period | |
Secondary | Network Modularity From EEG | EEG will be collected during a focused rest condition. Network modularity will be estimated from a matrix of connections between electrodes based on phase coherence, a unit-less measure of correlation between phase angles of EEG signals in the theta (4-8 Hz) frequency range. The modularity metric reflects the strength of modular network organization by summing the difference between the fraction of within-module connections to the total fraction of connections across modules, thus ranging from 0 (random) to 1 (completely modular). Change in network modularity will be analyzed for this data as change from before to after the intervention period. | Week 8, after the intervention period |
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