Clinical Trials Logo
  1. Home
  2. Other
  3. NCT03440801

A Randomized Comparison of Long-Term Healing Between Biodegradable- Versus Durable-Polymer Everolimus Eluting Stents in STEMI — CONNECT  

STEMI - ST Elevation Myocardial Infarction Clinical Trial

Official title:
A Randomized COmparison of LoNg-Term Vascular HealiNg bEtween Biodegradable -Polymer (BP) Versus Durable Polymer (DP) Everolimus Eluting Stents in Acute ST-Elevation Myocardial InfarCTion

Clinical Trial Summary

This study aims to compare the acute thrombogenecity and frequency of neoatherosclerotic lesions and other aspects of long term arterial healing such as the frequency of malapposed and uncovered stent struts at 3 years among patients treated with either a biodegradable polymer everolimus-eluting stent (Synergy) or a durable polymer everolimus-eluting stent (Xience Alpine) for STEMI.

Clinical Trial Description

DES use has significantly improved clinical outcomes as compared with bare metal stents (BMS), primarily through a notable reduction in the risk of repeat revascularisation. However, durable polymer DES have been associated with an increased risk of late and very late stent thrombosis and the anticipated development of in-stent neoatherosclerosis. In addition, in-vivo study suggest that different types of polymer among current DES might have different responses to acute thrombogenecity after stent implantation. Patients with STEMI are associated with worse long-term clinical outcomes due to re-infarction and stent thrombosis throughout long-term follow-up. Underlying unstable lesion which includes ruptured plaque and thin-cap fibroatheroma behind stent strut is a predictor of neoatherosclerosis formation. There is no dedicated randomized trial to comparing biodegradable-polymer versus durable polymer-DES in terms of acute thrombogenecity and long-term healing at 3 years after primary PCI. Therefore this study is designed to compare the acute thrombogenecity and frequency of neoatherosclerotic lesions and other aspects of long term arterial healing at 3 years among patients treated with either a biodegradable polymer everolimus-eluting stent (Synergy) or a durable polymer everolimus-eluting stent (Xience Alpine) for STEMI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03440801
Study type Interventional
Source Tokorozawa Heart Center
Contact
Status Active, not recruiting
Phase N/A
Start date July 3, 2017
Completion date June 30, 2024
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06013813 - Conventional vs. Distal Radial Access Outcomes in STEMI Patients Treated by PCI N/A
Terminated NCT04542889 - Coronary Microcirculation Assessment After Primary Angioplasty in Myocardial Infarction N/A
Recruiting NCT04951856 - Evolocumab or Normal Strategies to Reach LDL Objectives in Acute Myocardial Infarction Upbound to PCI Phase 4
Terminated NCT04459299 - CorPath GRX STEMI Study
Recruiting NCT05557019 - Semi Occlusion of the Coronary Sinus as an Adjunct to PCI in STEMI Patients, FIH Clinical Study N/A
Completed NCT03527940 - Prognostic Markers of Patients With STEMI
Not yet recruiting NCT03264859 - NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction N/A
Not yet recruiting NCT03182855 - Cangrelor vs. Ticagrelor for Early Platelet Inhibition in STEMI Phase 4
Not yet recruiting NCT03266289 - Evaluation of Short Term Outcome of Different Bifurcation Stenting Techniques at Assuit University Cath. Lab N/A
Withdrawn NCT04566289 - Observational Registry to Evaluate Real World Usage of PiCSO Impulse System in STEMI Patients as Part of Post-marketing Surveillance
Completed NCT04289012 - HELicobacter Pylori Screening in Patients With Acute Myocardial Infarction Pilot Study N/A
Not yet recruiting NCT04185077 - Bivalirudin in Late PCI for Oatients With STEMI Phase 4
Completed NCT03609346 - Asian Registry of the BioFreedom Stent for STEMI Patients
Recruiting NCT05107076 - Effect of PPCI on Diastolic Function & Levels of Galactin-3 in Patients With STEMI
Recruiting NCT02998853 - Non Culprit Functional Evaluation With 3D Angio QFR in STEMI PCI Procedure N/A
Completed NCT03677180 - National Cardiogenic Shock Initiative
Completed NCT03507777 - ILUMIEN IV: OPTIMAL PCI N/A
Recruiting NCT03863327 - EKG Criteria and Identification of Acute Coronary Occlusion
Completed NCT03070496 - Multicenter Cohort of STEMI Patients N/A
Active, not recruiting NCT03874338 - CLEAR SYNERGY Neutrophil Substudy