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Squamous Cell Carcinoma clinical trials

View clinical trials related to Squamous Cell Carcinoma.

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NCT ID: NCT06418516 Not yet recruiting - Clinical trials for Head and Neck Cancer

Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device

ANGELA
Start date: June 1, 2024
Phase: N/A
Study type: Interventional

Esophageal squamous cell carcinoma accounts for ~90% of the nearly half-million annual incident cases of esophageal cancer worldwide. The high costs and invasiveness of upper endoscopy constitute a limitation in providing adequate surveillance for at-risk individuals, including those with previous head and neck cancer. The ANGELA study is a prospective evaluation of the minimally-invasive capsule-sponge device, coupled with tissue biomarkers (p53-immunohistochemistry), to detect squamous neoplasia in high-risk individuals.

NCT ID: NCT06384924 Not yet recruiting - Clinical trials for Squamous Cell Carcinoma

Raman Spectroscopy and Skin Cancer

Start date: May 16, 2024
Phase:
Study type: Observational

The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors. The main question it aims to answer is: -Can Raman Spectroscopy help figure out how far a tumor spreads? This study will take measurements using laser light from an experimental, handheld probe by lightly touching the skin.

NCT ID: NCT05929547 Not yet recruiting - Clinical trials for Squamous Cell Carcinoma

Patient Perspectives in Squamous Cell Carcinoma Clinical Trials

Start date: July 2024
Phase:
Study type: Observational

Clinical research participation has historically been heavily biased toward specific demographics. This study will invite several participants to gather a wide range of information on clinical trial experiences for squamous cell carcinoma patients. The aim of the study is to identify the factors that limit the ability of a person to enroll in, as well as complete a clinical trial for treatment of squamous cell carcinoma. People with squamous cell carcinoma who are invited to take part in clinical research will benefit from the analysis of the data.

NCT ID: NCT05852665 Not yet recruiting - Clinical trials for Squamous Cell Carcinoma

Buccal Cancer Resection Ultrasound Guided

BRUG
Start date: September 1, 2023
Phase: N/A
Study type: Interventional

The aim of this research is to decrease the number of inadequate tumor-free margins, probably resulting in less adjuvant therapy, less local recurrences and better quality of life.

NCT ID: NCT05843032 Not yet recruiting - Clinical trials for Head and Neck Cancer

3D Ultrasound, Specimen Examination by Surgeon, and MRI in Surgical Margin Assessment

Start date: May 15, 2023
Phase: N/A
Study type: Interventional

In the current protocol, application of 3D ex-vivo ultrasound, MRI, and clinical evaluation (palpation and examination) by the surgeon is proposed to analyze the margin status in tongue squamous cell carcinoma and correlate the results to the histopathology findings.

NCT ID: NCT05065346 Not yet recruiting - Clinical trials for Head and Neck Squamous Cell Carcinoma

Neoadjuvant DaRT for Locally Advanced Oral Cavity SCC

Start date: March 2025
Phase: N/A
Study type: Interventional

A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device (DaRT) as a treatment prior to additional radiation or chemo therapy.

NCT ID: NCT04889742 Not yet recruiting - Prostate Cancer Clinical Trials

Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors

HETERERO
Start date: May 10, 2024
Phase: Phase 2
Study type: Interventional

This study investiagates deep-regional or superficial hyperthermia to enhance radiotherapy or chemoradiation in patients that suffer recurrent disease after previous radiotherapy.

NCT ID: NCT04595981 Not yet recruiting - Clinical trials for Squamous Cell Carcinoma

Chemo-embolization for Head and Neck Cancer

Start date: May 2025
Phase: Phase 2
Study type: Interventional

The study will evaluate whether adjuvant chemo-embolization increases progression free and/or overall survival relative to standard of care radiation and chemo- and/or immunotherapy in cisplatin-ineligible head and neck cancer patients with an acceptable morbidity rate.

NCT ID: NCT04533321 Not yet recruiting - Clinical trials for Squamous Cell Carcinoma

A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell Carcinoma

Start date: September 2020
Phase: Phase 2
Study type: Interventional

Afatinib is approved therapy for SCC of the lung after progression with standard of care chemotherapy. There is also evidence of improvement of progression free survival of patients with metastatic/recurrent SCC of the head and neck after failure of chemotherapy in patients treated with afatinib. Therefore, treatment of patients with these 2 conditions with afatinib is not experimental, and will follow conventional clinical management.

NCT ID: NCT03837613 Not yet recruiting - Cancer Clinical Trials

Prognostic Value of Tumor Thickness of Buccal Mucosa Squamous Cell Carcinoma on the Incidence of Nodal Metastasis.

Start date: February 2019
Phase:
Study type: Observational

Does the tumor thickness value of buccal squamous cell carcinomas, predict cervical nodal metastasis in clinically and radio-graphical neck negative (N0) thus sparing such patients unnecessary surgical procedures and it's associated morbidities? The aim of the study is to evaluate the prognostic value of tumor thickness cut off 4 mm in predicting cervical nodal metastases in a population of Egyptian patients presenting with Buccal Squamous Cell Carcinoma. The hypothesis is that patients with tumor thickness less than 4 mm will present with significantly less cervical nodal metastasis.