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Clinical Trial Summary

The primary goal of this project is to describe the clinical and physiologic characteristics of Spontaneous Coronary Artery Dissections (SCAD) in order to increase awareness, understanding, treatment and prevention of a potentially fatal cardiovascular event. This study will be a retrospective and prospective review of medical course and current health of men and women with SCAD.


Clinical Trial Description

Spontaneous Coronary Artery Dissection (SCAD) is a relatively rare and poorly understood condition that has been reported to affect more women than men. The coronary arteries consist of three layers, and dissection occurs when two of these layers separate, enabling blood to flow into the space between the layers. As the blood accumulates, this can cause obstruction to normal blood flow within the heart, leading to chest pain, heart attack and even sudden death. The medical community has much to learn about treatment and prevention of this potentially fatal cardiovascular event. Mayo Clinic is conducting two studies of SCAD. This study consists of building a database/registry of patients with SCAD (whether they have been patients at Mayo Clinic or not) to identify patterns of SCAD incidence, causes and associations that could guide future research. With participant consent, Mayo Clinic staff will request a copy of the original coronary angiogram when SCAD was diagnosed to confirm the diagnosis and determine eligibility. If eligible, study coordinators will contact the participant to provide more information about the studies and request a signed informed consent document. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01429727
Study type Observational
Source Mayo Clinic
Contact Susan Milbrandt
Phone 507-266-3180
Email mayoscad@mayo.edu
Status Recruiting
Phase
Start date July 2011
Completion date December 2030

See also
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Completed NCT03390998 - Angiographic and Psychosocial Evaluation of Peripartum vs. Non: SCAD
Completed NCT02799186 - The Study of the Prevalence Fibromuscular Dysplasia in Patient With Haematoma or Spontaneous Coronary Artery Dissection. N/A
Enrolling by invitation NCT01427179 - Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Recruiting NCT04496687 - International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
Active, not recruiting NCT02188069 - Canadian SCAD Study
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Recruiting NCT05699200 - A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection N/A
Recruiting NCT03607981 - Spanish Registry on Spontaneous Coronary Artery Dissection
Completed NCT04415762 - Spontaneous Coronary Artery Dissection Registry (DIssezioni Spontanee COronariche ITalian-SPAnish)
Recruiting NCT04906356 - Canadian SCAD Study
Recruiting NCT04457544 - Spontaneous Coronary Artery Dissection National Swiss Registry
Not yet recruiting NCT04850417 - Randomized Study of Beta-Blockers and Antiplatelets in Patients With Spontaneous Coronary Artery Dissection Phase 4
Withdrawn NCT03335020 - Using Ultrasonography, Shear Wave Elastography, Strain Imaging, and 3-D Volume Ultrasonography on Cardiovascular Disease Phase 1