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Spasticity clinical trials

View clinical trials related to Spasticity.

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NCT ID: NCT00702468 Completed - Multiple Sclerosis Clinical Trials

Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis

Start date: November 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the maintenance of effect after long-term treatment with Sativex® in subjects with symptoms of spasticity due to Multiple Sclerosis (MS) who have been receiving long-term benefit from treatment with Sativex®.

NCT ID: NCT00681538 Completed - Multiple Sclerosis Clinical Trials

A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)

Start date: January 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether Sativex® versus Placebo is effective in the relief of symptoms of spasticity in subjects with multiple sclerosis, who have been identified as having a capacity to respond to Sativex.

NCT ID: NCT00607542 Completed - Cerebral Palsy Clinical Trials

Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity

Best PK/PD
Start date: November 2008
Phase: Phase 1/Phase 2
Study type: Interventional

Oral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although for adults there is dosing,safety and efficacy information in the package insert, this is not the case for children. The purpose of this study is to determine how fast the drug is cleared from the body, the correct dose, and long-term safety and efficacy for children with spasticity.

NCT ID: NCT00575536 Completed - Spasticity Clinical Trials

Optical Stimulation in Peripheral Nerves for Select Rhizotomy Procedures

Rhizotomy
Start date: January 2006
Phase:
Study type: Observational

The purpose of this study is to determine the safe and effective levels of optical stimulation in peripheral nerves of humans otherwise undergoing nerve lesioning in surgery.

NCT ID: NCT00572845 Terminated - Spasticity Clinical Trials

Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation

Start date: January 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if there is a relationship between spasticity and relative changes in Basal Energy Expenditure in persons with spinal cord injury.

NCT ID: NCT00472914 Completed - Cerebral Palsy Clinical Trials

Use of EMG to Assess Clinical Hypertonia

Start date: January 2007
Phase: Phase 1/Phase 2
Study type: Observational

A handheld surface electromyography device will be tested by clinicians on children with limb hypertonia, and inter-rater reliability will be assessed with and without the device.

NCT ID: NCT00464958 Terminated - Multiple Sclerosis Clinical Trials

One Year Extension Study To Protocol C2/5/TZ:MS-05

Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

Open label, one year extension study to evaluate the clinical efficacy and safety of 12 mg sublingual tizanidine administered once nightly in MS patients who successfully completed Phase I/II protocol C2/5/TZ:MS-05 at the Tel Aviv Sourasky Medical Center, Department of Neurology, Dr. Arnon Karni, PI.

NCT ID: NCT00367068 Completed - Cerebral Palsy Clinical Trials

Dutch National ITB Study in Children With Cerebral Palsy

Start date: January 2002
Phase: Phase 3
Study type: Interventional

The objective of this study is to determine the efficacy and safety of treatment with intrathecal baclofen for severe spasticity in children with cerebral palsy.

NCT ID: NCT00337688 Completed - Cerebral Palsy Clinical Trials

Power Wheelchair Joystick Use in Spastic Cerebral Palsy

Start date: July 2006
Phase: N/A
Study type: Observational

There are over 750,000 individuals in the U.S. with Cerebral Palsy (CP). Up to 46% of adults with CP report limited mobility in their communities. However, upper limb spasticity and problems with movement can make the independent use of a wheelchair difficult. Forty percent of individuals who desire mobility via electric wheelchairs are precluded from using them because of problems with upper limb function. No studies to date have produced devices that definitively improve mobility for these individuals. We will recruit 22 subjects with Spastic CP and 22 age and gender matched control subjects without apparent disability from advertisements, mailings, and outpatient clinics. Both a conventional joystick (MSJ) and a novel joystick that is customized for each subject will each be used six different computer screen tasks that simulate driving a wheelchair on a path. We will compare subjects and joysticks based on driving performance. Understanding problems with driving will help us to design joysticks and other assistive devices, not only for CP but for Traumatic Brain Injury, Spinal Cord Injury, Parkinson's Disease, stroke, or a variety of other disabilities.

NCT ID: NCT00282191 Completed - Spasticity Clinical Trials

Prevalence of Spasticity in Adults With Mental Retardation Living in the Community

Start date: August 2006
Phase: Phase 1
Study type: Observational

This survey aims to investigate the prevalence of spasticity among adults who live in community settings in Davidson County, Tennessee. The treatment of spasticity in those who live in community homes could significantly increase a person's quality of life by allowing them to participate more independently in activities of daily living, or by making assistance easier for caregivers.