Intravital Microscopy in Human Solid Tumors

Status Completed

Clinical Trial Summary

This study will investigate the tumor-associated vasculature of patients with solid tumors. The investigators will use a technology known as intravital microscopy (IVM) in order to visualize in real-time the vessels associated with solid tumors. The IVM observations may determine if an individual patient's tumor vessels would be amenable to receiving systemic therapy, based on the functionality of the vessels.

Clinical Trial Description

PRIMARY OBJECTIVE: To determine the feasibility and clinical utility of performing HIVM in patients with solid tumors during standard course of treatment (surgical resection). SECONDARY OBJECTIVES: 1. Compare the microscopic observation of the tumor-associated vessels with normal tissue (e.g. peritoneal surface or normal brain tissue) in each individual subject. 2. Correlate the microscopic observations of the tumor-associated vessels with pathologic grade of tumor. 3. To correlate the microscopic observation of the microvasculature with tumor-specific and overall survival. OUTLINE: Patients receive fluorescein intravenously (IV) and undergo HIVM over 1-2 minutes per field. After completion of study, patients are followed up at 2-3 weeks after surgery. ;

Study Design

Related Conditions & MeSH terms

Brain Neoplasms
Carcinoma
Clinical Stage IV Gastric Cancer AJCC v8
Colorectal Neoplasms
Gastric Carcinoma
Malignant Solid Neoplasm
Metastatic Colorectal Carcinoma
Metastatic Gastric Carcinoma
Metastatic Sarcoma
Neoplasms
Pancreatic Neoplasms
Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8
Resectable Colorectal Carcinoma
Resectable Pancreatic Carcinoma
Resectable Sarcoma
Sarcoma
Solid Tumor, Adult
Stage IV Colorectal Cancer AJCC v8
Stomach Neoplasms

Clinical Trial Details

NCT number	NCT03823144
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Completed
Phase	N/A
Start date	February 28, 2019
Completion date	December 31, 2023

View Details

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