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Breath Biomarkers for Sleep Loss and Circadian Timing

Sleep Disorders, Circadian Rhythm Clinical Trial

Official title:
Breath Biomarkers for Sleep Loss and Circadian Timing

Clinical Trial Summary

Insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency. The current study aims to use a cutting-edge technology, small molecule analysis (e.g. metabolomics), to detect compounds in breath that reliably change with sleep-wake state and those whose levels vary by time of day.

Clinical Trial Description

The goal of the study is to use a small molecule analysis (e.g. metabolomics) device to measure compounds in breath that may change with sleep-wake state and compounds that vary by time of day. Participants will be fitted with a plastic mask connected to the device for a breath analysis test for about 20 minutes. Then, participants may be asked to lie down and take a nap or to remain sitting/lying down for 1-2 hours. After such time, participants will be asked to complete another ~20 minute breath analysis test. Participants will be asked to complete questionnaires throughout the study session. Investigators may ask participants to provide up to two saliva samples during the study session. Participants will also be asked to complete a pre-study diary to document sleep/wake times, diet, and medications for the day before the study session. Participants may be asked if they would be willing to take part in an additional study session on another day. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03980340
Study type Observational
Source Brigham and Women's Hospital
Contact
Status Active, not recruiting
Phase
Start date January 28, 2021
Completion date September 30, 2024
View Details
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