Biomarkers for Circadian Timing in Healthy Adults

Sleep Disorders, Circadian Rhythm Clinical Trial

Official title: Proteomic and Transcriptomic Biomarkers of Circadian Timing

Status Recruiting

Clinical Trial Summary

Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.

Clinical Trial Description

There is an urgent need for a practical way to assess circadian timing accurately in both general and sleep medicine. The study is designed to assess the levels of different biomarkers in the blood taken from frequent samples across three separate sleep-wake conditions - Conventional/Normal sleep-wake conditions (baseline), extended wake/acute sleep deprivation (constant routine), and during irregular sleep-wake conditions (inverted day). Participants will be asked to complete medical, psychological, and sleep-wake evaluations prior to the study. Upon completion of screening, if eligible, participants will stay 7 consecutive days and nights in the sleep research laboratory within the hospital. ;

Related Conditions & MeSH terms

• Advanced Sleep Phase
• Advanced Sleep Phase Syndrome
• Advanced Sleep Phase Syndrome (ASPS)
• Delayed Phase Sleep Syndrome
• Delayed Sleep Phase
• Delayed Sleep Phase Syndrome
• Irregular Sleep-Wake Syndrome
• Non-24 Hour Sleep-Wake Disorder
• Parasomnias
• Shift Work Type Circadian Rhythm Sleep Disorder
• Shift-Work Sleep Disorder
• Sleep Disorders, Circadian Rhythm
• Sleep Disorders, Intrinsic
• Sleep Wake Disorders
• Syndrome

• NCT number: NCT03956745
• Study type: Observational
• Source: Brigham and Women's Hospital
• Contact: Research Study Coordinator
• Phone: 617-525-8813
• Email: BodyClockStudy@research.bwh.harvard.edu
• Status: Recruiting
• Start date: June 1, 2021
• Completion date: May 2024