Sleep Apnea, Coronary Atherosclerosis and Heart Failure in Diabetes Patients With Nephropathy

Sleep Apnea Clinical Trial

— SLEEP  

Official title:

Sleep Apnea, Coronary Atherosclerosis and Heart Failure in Diabetes Patients With Nephropathy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04549324
• Other study ID #: 1-10-72-122-20
• Status: Completed
• Start date: October 1, 2020
• Est. completion date: January 24, 2022

Study information

• Verified date: October 2021
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Background:

Diabetes, and especially diabetic kidney disease is associated with the development of cardiovascular disease such as calcification in the coronary arteries and heart failure. Sleep apnea is frequent among patients with diabetes and diabetic kidney disease and sleep apnea itself is a solitary risk factor in the development of cardiovascular disease. Nonetheless, sleep apnea is underdiagnosed in diabetes patients because of a discrepancy between sleep apnea severity and actual oxygen deficiency symptoms which makes the diagnosis difficult. For that reason, many diabetics have undiagnosed sleep apnea together with cardiovascular disease. Early discovery of sleep apnea among high risk diabetic patients may therefore be considered crucial before cardiovascular complications develop. For this reason, sleep apnea screening of high-risk diabetics can possibly improve early diagnostics of cardiovascular disease.

Aim:

This study will seek to establish the association between obstructive sleep apnea (OSA) and coronary calcification and heart failure in patients with diabetic kidney disease. The basic hypothesis of the study is that patients with diabetic kidney disease and concurrent OSA have a higher prevalence and severity of coronary calcification and heart failure compared to patients without OSA.

Methods:

Diabetic adult patients with scheduled check-ups at Steno Diabetes Center Aarhus, or Department of Renal Medicine on Aarhus University Hospital will be included in the study.

Firstly, all included patients are screened for sleep apnea with the devices SomnoTouch® and ApneaLink®. Based on the sleep apnea determination; 40 patients with moderate-severe sleep apnea are compared with 40 patients without sleep apnea. In both groups, the patients are examined for calcification in the coronary vessels using a CT-scan while the function of the heart is examined by ultrasound (echocardiography). The stiffness of aorta is measured and performed using radial artery tonometry (SphygmoCor®).

Furthermore, range of blood- and urine samples will be performed

The perspectives are that patients with diabetes should be regularly evaluated for sleep apnea and that patients with moderate/severe sleep apnea should undergo further examination for cardiovascular disease even though the patients don't display any symptoms of either cardiovascular disease or sleep apnea.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 74
• Est. completion date: January 24, 2022
• Est. primary completion date: January 24, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• = 18 years.

• Diabetes Mellitus Type 2 with an eGFR between 10-60 ml/min/1,73 m^2 (Equalling CKD-group 3, 4 and 5 non-dialysis).

Exclusion Criteria:

• Known sleep apnea in continuous positive airway pressure(CPAP) treatment.

• Known mild sleep apnea (AHI 5-14) after the sleep apnea measurement.

• Participants with central apnea (> 50 % of central apnea episodes in the AHI = 15 group.) or Cheyne Stokes after the sleep apnea measurement.

• < 4 hours of recording (ApneaLink)

• Known coronary arterial disease with previous revascularization (PCI or CABG)

Related Conditions & MeSH terms

• Apnea
• Arterial Stiffness
• Atherosclerosis
• Coronary Artery Disease
• Coronary Atheroscleroses
• Diabetic Nephropathies
• Diabetic Nephropathy Type 2
• Heart Failure
• Heart Insufficiency
• Kidney Diseases
• Myocardial Ischemia
• Sleep Apnea
• Sleep Apnea Syndromes
• Vascular Diseases

Locations

Country	Name	City	State
Denmark	Aarhus University Hospital	Aarhus

Sponsors (1)

Lead Sponsor	Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The association between sleep apnea and coronary atherosclerosis (Agatston Score) measured with cardiac CT-scan in patients with diabetic nephropathy.	The degree of atherosclerosis in the coronary artery walls is evaluated by cardiac CT-scan and subsequent quantified by Agatston score. Patients with an estimated glomerular filtration rate (eGFR) = 25 ml/min/1,73 m2 is scanned without contrast whereas patients with an eGFR 26-60 ml/min/1,73 m2 are screened with contrast.; All Agatston scoring will be performed by a cardiologist blinded to information on patient biochemical characteristics and AHI. The only biochemical parameter which the cardiologist is not blinded to is eGFR.	Cardiac CT-scan will be performed no later than 1 month after inclusion. All Agatston scores will be estimated straight after the cardiac CT-scan.
Primary	The association between sleep apnea and systolic function in patients with diabetic nephropathy.	All patients included in the study will undergo transthoracic echocardiography. Systolic function is evaluated by two-dimensional automated evaluation of ejection fraction (2-D auto-EF).; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Primary	The association between sleep apnea and diastolic heart failure in patients with diabetic nephropathy.	All patients included in the study will undergo transthoracic echocardiography. Diastolic function is evaluated by E/e´.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Primary	The association between sleep apnea and systolic function in patients with diabetic nephropathy.	All patients included in the study will undergo transthoracic echocardiography. Systolic function is evaluated by Left Ventricular Global Longitudinal Strain (GLS).; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	The association between sleep apnea and coronary plaque volume in patients with diabetic nephropathy.	Coronary plaque volume is estimated by a cardiac CT-scan with contrast.; All coronary plaque volume analysing will be performed by a cardiologist blinded to information on patient biochemical characteristics and AHI. The only biochemical parameter which the cardiologist is not blinded to is eGFR.	Cardiac CT-scan will be performed no later than 1 month after inclusion.
Secondary	Association of sleep apnea and aortic stiffness (defined as Pulse Wave Velocity (PWV)) in patients with diabetic nephropathy.	To get a non-invasive estimate of the aortic stiffness, measurement of Pulse Wave Velocity (PWV) (carotid-femoral and carotid-radial) will be performed. PWV will be recorded with the Sphygmocor® device according to regular protocol. If possible, two acceptable measurements will be conducted for each included patient. Calculation of PWV will be performed automatically by the device using a previously published formula.	PWV is performed the same day as the patient is included.
Secondary	Association between Matrix Gla Protein (MGP) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy. MGP, a novel biochemical marker of arterial calcification, will be collected and analysed in all patients.	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between Calcification propensity score (T50test) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy. Calcification propensity score (T50test) will be collected and analysed in all patients.	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between sRANKL (soluble receptor activator of nuclear factor kappa-B ligand) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy. sRANKL (soluble receptor activator of nuclear factor kappa-B ligand) will be collected and analysed in all patients.	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between 25-OH-Vitamin D(D3+D2) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy. 25-OH-Vitamin D(D3+D2) will be collected and analysed in all patients.	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between Fetuin-A(alfa-2-Heremans Schmid glycoprotein; AHSG) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy. Fetuin-A(alfa-2-Heremans Schmid glycoprotein; AHSG) will be collected and analysed in all patients	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021.
Secondary	Association between Sclerostin and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy., Sclerostin will be collected and analysed in all patients	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between osteoprotegerin and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy., osteoprotegerin will be collected and analysed in all patients.	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between BsAP (bone-specific alkaline phosphatase) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy., BsAP (bone-specific alkaline phosphatase) will be collected and analysed in all patients	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between TRAP5B (tartrate-resistant acid phosphatase 5b) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy, TRAP5B (tartrate-resistant acid phosphatase 5b) will be collected and analysed in all patients.	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between P1NP (procollagen type 1 N propeptide) and coronary calcification in patients with sleep apnea and diabetic nephropathy.	To establish a deeper understanding of the pathogenesis of central arterial calcification in patients with sleep apnea and diabetic nephropathy., P1NP (procollagen type 1 N propeptide) will be collected and analysed in all patients	Analysis will be performed as batch-analysis at the end of inclusion of patients summer 2021
Secondary	Association between LVEDd (Left ventricular end diastolic diameter) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between LVEDs (Left ventricular end systolic diameter) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between IVSd (Interventricular Septal Thickness at Diastole) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between IVSs (Interventricular Septal Thickness at Systole) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between PWTd (Posterior wall thickness at end-diastole) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between PWTs (Posterior wall thickness at end-systole) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Aorta (sinus valsalva) diameter as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Aorta (Ascendens) diameter as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Aorta (Abdominalis) diameter as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between maximum Vena Cava Inferior diameter as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between minimum Vena Cava Inferior diameter as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Early mitral inflow velocity (E) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Late mitral inflow velocity (A) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between E/A-ratio as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Deceleration time of early diastolic transmittal flow (dtE) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between Right ventricular diameter (RVD) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus.; The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between left atrial volume (LAV) as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus. The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan
Secondary	Association between 2D atrial global strain as determined during echocardiography and sleep apnea in patients with diabetic nephropathy.	All patients included in this study will undergo echocardiography. In particular systolic and diastolic function will be in focus. The echocardiographic-clinician is blinded to AHI-status.	Transthoracic echocardiography will be performed no later than 1 month after inclusion and prior to cardiac CT-scan