<b>Gestational</b> <b>Diabetes</b> Genetic and Socioeconomic Risk Study OneinSeven <b>Gestational</b> <b>Diabetes</b> Genetic and Socioeconomic Risk Study
The objective of the Gestational Diabetes Genetic Socioeconomic Risk Study is to generate genome wide association study data (GWAS) to calculate polygenic risk scores (PRS) for the development of gestational diabetes in pregnant women. Oshun Medical's GWAS study will be conducted by collecting DNA samples alongside medical and socioeconomic data and applying data science methodology to generate a polygenic risk score algorithm for gestational diabetes. Our hypothesis is that key genetic variants linked to gestational diabetes will be identified, and sociodemographic characteristics may impact epigenetic factors which further contribute to this risk of gestational diabetes. The PRS generated through our study will be combined with an analysis of epigenetic factors to produce a new method for predicting risk of developing gestational diabetes during pregnancy.
NCT04789473 — Pregnancy Related
Status: Recruiting
http://inclinicaltrials.com/pregnancy-related/NCT04789473/
Evaluation of Knowledge Regarding <b>Gestational</b> <b>Diabetes</b> and Evaluation of (Group) Education for <b>Gestational</b> <b>Diabetes</b>
Prospective observational cohort study of women with gestational diabetes (GDM) based on the 'International Association of Pregnancy Study Groups' (IADPSG) criteria. The overall aim is to evaluate the knowledge regarding GDM of women with GDM and to evaluate the satisfaction of women with GDM about the education they receive (given in group or individually). Normal routine care is followed and evaluated.
NCT02528162 — Gestational Diabetes
Status: Completed
http://inclinicaltrials.com/gestational-diabetes/NCT02528162/
Healthy Eating and Active Living for <b>Diabetes</b> - <b>Gestational</b> <b>Diabetes</b> Mellitus
To examine the effectiveness of a group-based lifestyle modification program followed by peer-led telephone counselling for type 2 diabetes (T2D) and cardiovascular disease risk reduction. The lifestyle modification program will support daily ambulatory activity and low glycemic index food intake among women with previous gestational diabetes mellitus (GDM).
NCT02483949 — Diabetes Mellitus Gestational Previous Pregnancy
Status: Completed
http://inclinicaltrials.com/diabetes-mellitus-gestational-previous-pregnancy/NCT02483949/
Decreasing the Incidence of Post-partum Type II <b>Diabetes</b> Mellitus in <b>Gestational</b> <b>Diabetes</b> Population- Prospective Randomized Controlled Trial
The goal of the study is to examine the impact of an educational video on the rate of breastfeeding in mothers who had gestational diabetes mellitus, and the rate of type-II diabetes mellitus diagnosed postpartum.
NCT05202002 — Diabetes Mellitus, Type 2
Status: Recruiting
http://inclinicaltrials.com/diabetes-mellitus-type-2/NCT05202002/
Prevention of Type 2 <b>Diabetes</b> and <b>Gestational</b> <b>Diabetes</b> Among Women of Reproductive Age in Kisantu, Democratic Republic of Congo
This study aims to develop and implement a long-term program focused on the prevention of type 2 diabetes Mellitus (T2DM) and gestational diabetes mellitus (GDM) in women of reproductive age through lifestyle modification. This is a cluster-randomized trial whereby 6 health centers across Kisantu, Democratic Republic of Congo (DRC) will be randomized to an intervention group (3 health centers) or a comparison group (3 health centers). The intervention group will be provided with a preventive program based on educational + motivational strategies when the comparison group will be limited to an educational strategy only. This study will last 24 months and is limited to women of reproductive age (18-49 years), pregnant and non-pregnant. Evaluation of this research will use mixed longitudinal analyses for healthy lifestyle adherence, anthropometric and clinical indicators, diet quality, and physical activity. Expected results of this study for women of reproductive age include the prevention of T2DM and GDM through the acquisition of healthy lifestyle behavior, reaching and maintaining an optimal weight, blood pressure and glycemia, and adhere to the weight gain recommendations during pregnancy. Other expected achievements encompass improvements in the usability of data capturing systems, expand knowledge among health care providers on effective strategies for T2DM and GDM prevention and improve the technique and precision of measurements concerning health visits among health care providers, among others.
NCT05039307 — Diabetes Mellitus, Type 2
Status: Active, not recruiting
http://inclinicaltrials.com/diabetes-mellitus-type-2/NCT05039307/
Liraglutide in the Prevention of Type 2 <b>Diabetes</b> After <b>Gestational</b> <b>Diabetes</b>
Obese women with history of gestational diabetes are in great danger to develop type 2 diabetes (T2D) within 5-10 years after delivery. Aim of the study is to investigate if 12 months' liraglutide treatment could decrease the risk of T2D in obese women who have had gestational diabetes. The women are randomized either to liraglutide (Victoza ® 1.8 mg) or placebo group, once daily. Same laboratory tests are taken and instructions given at baseline 6 month and one year. After one year visits once a year until 5 years with same laboratory tests and measurements are taken.
NCT04324229 — Gestational Diabetes
Status: Active, not recruiting
http://inclinicaltrials.com/gestational-diabetes/NCT04324229/
Study of Betatrophin Levels in Patients With Type 2 <b>Diabetes</b> and <b>Gestational</b> <b>Diabetes</b> and Healthy Subjects
Betatrophin is a newly identified hormone that promotes pancreatic beta cell proliferation, improves glucose tolerance and regulates lipids metabolism. A recent study showed that circulating concentrations of betatrophin doubled in type 1 diabetes. The objective of this study is to investigate the association of serum betatrophin levels with the progression of diabetic retinopathy in patients with type 2 diabetes and the level of betatrophin in gestational diabetes patients and pregnant women.
NCT02025673 — Type 2 Diabetes
Status: Active, not recruiting
http://inclinicaltrials.com/type-2-diabetes/NCT02025673/
Increasing Adoption of Early Intervention to Prevent <b>Diabetes</b> After <b>Gestational</b> <b>Diabetes</b> Mellitus
The Avoiding Diabetes After Pregnancy Trial (ADAPT) study was designed to test the effectiveness of interventions that potentially increase the adoption of Diabetes Prevention Program (DPP) elements by women who had a pregnancy with gestational diabetes mellitus (GDM). The study was conducted as an integrated trial with two separate arms: one to facilitate weight reduction and the other to increase diabetes testing. There were two hypotheses: 1. Women in the testing intervention will be more likely to have received a diabetes test within the 6 months post-intervention than women in the control group. 2. Women in the weight reduction intervention will have lost more weight at the 6-month and 9-month follow-up than women in the control group. The primary study aim was to determine the efficacy of a system of interactive technology-based supports to prompt women with a history of gestational diabetes to take steps to prevent diabetes. The secondary aims were focused on women's engagement: - To evaluate the impact of the weight reduction intervention in terms of participant engagement with the interactive technology-based supports. - To evaluate changes in the women's perception of their personal diabetes risk following after exposure to information about diabetes risk following a pregnancy with GDM. - To identify the determinants and motivators of and barriers to diabetes testing in the 6- to 12-week postpartum period and thereafter, using the Health Belief model to guide the study. There was an additional secondary aim involving metformin: - To evaluate the impact of the diabetes risk reduction intervention in terms of women seeking out their physician's advice on metformin treatment and receiving a metformin prescription, if appropriate.
NCT01923350 — Weight Reduction
Status: Completed
http://inclinicaltrials.com/weight-reduction/NCT01923350/
Dulce Mothers: A Community Approach to Reduce the Risks of Developing <b>Diabetes</b> After <b>Gestational</b> <b>Diabetes</b>
Objective: The current study examined the effectiveness of a culturally-appropriate adaptation of the diabetes prevention program (DPP) curriculum in reducing type 2 diabetes risk in Latinas with a history of gestational diabetes mellitus (GDM). Research Design and Methods: Seventy-six Latinas aged 18-45 years with GDM in the past 3 years participated in an 8-week group-based, peer-educator led lifestyle intervention based on the DPP, with adaptations appropriate to Latino culture and recent mothers. Clinical and self-report indicators were assessed at baseline, post-intervention (month-3), and follow-up (month-6). Hypothesis-The modified culturally tailored DPP will improve risk factors associated with the development of type 2 DM.
NCT01613937 — Diabetes
Status: Completed
http://inclinicaltrials.com/diabetes/NCT01613937/
Translational <b>Diabetes</b> Prevention in GDM
The purpose of this research study is to implement and evaluate a lifestyle program designed to help women who have high glucose levels during pregnancy make healthful diet and physical activity changes to lose weight. Eligible women will be randomly assigned to life-style intervention or usual medical care.
NCT01489163 — Gestational Diabetes
Status: Completed
http://inclinicaltrials.com/gestational-diabetes/NCT01489163/