Multi-center Imaging Genetics Studies in China

Schizophrenia Clinical Trial

— CHIMGEN  

Official title:

Multi-center Imaging Genetics Studies in China

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02681822
• Other study ID #: 81425013
• Status: Recruiting
• Start date: November 2015
• Est. completion date: December 2020

Study information

• Verified date: April 2019
• Source: Tianjin Medical University General Hospital
• Contact: Chunshui Yu, PhD
• Email: chunshuiyu[@]vip.163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To study the impact of genetic and environmental factors on high-level cognition associated neural circuits among healthy young Chinese Han subjects.

Description:

The investigators plan to collect behavioral assessment and environmental factors data,peripheral blood sample, MRI brain images in more than 10,000 healthy young Chinese Han individuals in order to build the pathway from gene to high-level cognitive phenotypes.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10000
• Est. completion date: December 2020
• Est. primary completion date: December 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• aged 18-30

• Chinese Han

• right-handed

• without history of neuropsychiatric disease

• no substance addiction

• smoking

Exclusion Criteria:

• younger or elder than 18-30 year-old

• other ethnics

• with history of neuropsychiatric disease

• with history of neuropsychiatric disease among first,second and third degree relatives

Related Conditions & MeSH terms

• Alzheimer Disease
• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Major Depressive Disorders
• Schizophrenia

Locations

Country	Name	City	State
China	Tianjin Medical University General Hospital	Tianjin	Tianjin

Sponsors (52)

Lead Sponsor

Collaborator

Tianjin Medical University General Hospital

Beijing Hospital, Beijing Normal University, Beijing Tongren Hospital, Central South University, Chinese Academy of Science Institute of Automation, Chinese PLA General Hospital, First Affiliated Hospital of Chongqing Medical University, First Affiliated Hospital of Wenzhou Medical University, First Affiliated Hospital Xi'an Jiaotong University, First Hospital of Jilin University, Guangdong General Hospital, Guangdong No.2 Provincial People's Hospital, Henan Provincial Hospital, Huashan Hospital, Inner Mongolia Medical College Hospital, LanZhou University, Nanjing PLA General Hospital, Peking Union Medical College Hospital, Pingjin Hospital,Logistics University of Chinese People's Armed Police Forces, Qilu Hospital of Shandong University, RenJi Hospital, School of Medical Imaging, Tianjin Medical University, Second Affiliated Hospital of Wenzhou Medical University, Second Affiliated Hospital, School of Medicine, Zhejiang University, Shan dong Medical Imaging Research Institute, South China Normal University?Hainan General Hospital, Southwest Hospital, China, Tang-Du Hospital, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, The First Affiliated Hospital of Anhui Medical University, The First Affiliated Hospital of Dalian Medical University, The First Affiliated Hospital of Shanxi Medical University, The First Affiliated Hospital of Zhengzhou University, The First Affiliated Hospital with Nanjing Medical University, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, The Frist Hospital Of China Medical University, The Second Hospital of Hebei Medical University, The University of Science and Technology of China, Tianjin First Central Hospital, Tianjin Huanhu Hospital, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University Second Hospital, Tongji Hospital, University of Electronic Science and Technology of China, West China Hospital, Wuhan University, Xiangya Hospital of Central South University, Xijing Hospital, Xuanwu Hospital, Beijing, Xuzhou Medical University, Yantai Yuhuangding Hospital

Country where clinical trial is conducted

China, 

References & Publications (2)

Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 4;31(18):6764-70. doi: 10.1523/JNEUROSCI.5794-10.2011. — View Citation

Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993 Aug 13;261(5123):921-3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain structure and function measured by MRI scans	The participants will receive non-interventional multi-modal MRI scans, such as 3D-T1WI, DTI, DKI, ASL, REST-fmri, then the investigators can acquire the brain volume in region of interest, such as bilateral hippocampus.	2 years
Secondary	Childhood adversities as assessed by Childhood Trauma Questionnaire-Short Form (Chinese Version)	To investigate impact of the adversities in early life of participants on brain structure and function as well as the interaction effect of childhood adversities and genetic variations,such as 5-HTTLPR polymorphism.	2 years