Keloid Clinical Trial
Official title:
Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)
Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids and hypertrophic Scars)
On a yearly basis, millions develop different skin scarring. These scars are a public reminder of the traumatic incident, past or present disease or a surgery which caused them. Scarring is a common consequence of wound healing process, and it is one of the most complex biological processes in human. This healing process is affected by numerous factors and thus can be disrupted, leading to pathological scarring. Pathological scarring is common in people with genetic predisposition, those undergone complex and massive surgeries, burns or those wounded in unsanitary environments. Apart from being aesthetically unpleasant, scars are associated with functional and psychosocial morbidities. Despite clinical, pathologic and pathogenic differences between keloids and hypertrophic scars, treatments are similar. Scars have a negative external impact causing social distress and impaired self-image, and as a consequence, low satisfaction rates following surgical and cosmetic procedures. The first line treatment is monthly intralesional corticosteroid injections with a response rate of 50-100% and recurrence of 50%. There are a few steroids available and used for abnormal scars treatment, including Celestone chronodose (Betamethasone acetate + Betamethasone sodium phosphate), Dexamethasone sodium phosphate, Methylprednisolone acetate, Methylprednisolone sodium succinate, Methylprednisolone hemisuccinate, Triamcinolone acetonide. Steroids are different by their hydrophilic properties, potency and half-life, although the half-life of intralesional injections is not known. Inspite of being widely used, there have never been a comparative study of the different steroid treatments. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02923596 -
Retrospective Study of Keloid Disorder
|
N/A | |
| Completed |
NCT02922972 -
Treatment of Keloid Scar by Autologous Platelet Rich Plasma Obtained With RgenKit-BCT
|
N/A | |
| Terminated |
NCT01478243 -
Study of Psycho-Social Impact of Keloid
|
N/A | |
| Recruiting |
NCT01423383 -
Epidemiology Study of Keloid
|
N/A | |
| Completed |
NCT03228693 -
Gene Expression and Biomarker Profiling of Keloid Skin
|
N/A | |
| Not yet recruiting |
NCT04326959 -
Implantation of Mesenchymal Stem Cell, Conditioned Medium, or Triamcinolone Acetonide for Keloid
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03312166 -
Compressive Device to Prevent Keloïd Scars Recurrence [SCARWARS]
|
N/A | |
| Recruiting |
NCT02823236 -
Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars
|
Phase 3 | |
| Recruiting |
NCT04597060 -
The Safety and Efficacy of Thermo-mechanical System for Fractional Ablation Associated Triamcinolone Acetonide Drug Delivery for the Treatment of Hypertrophic Scars and Keloids
|
N/A | |
| Completed |
NCT05887804 -
Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial
|
Phase 4 | |
| Completed |
NCT05939817 -
The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial
|
Phase 4 | |
| Completed |
NCT03630198 -
Pain Outcomes Following Intralesional Corticosteroid Injections
|
Phase 4 | |
| Completed |
NCT04169438 -
Pilot Study Investigating a Restorative Wound Care Cream Together With Petrolatum on Surgical Excisions
|
N/A | |
| Recruiting |
NCT01423981 -
Web Based Investigation of Natural History of Keloid Disorder, an Online Survey
|
N/A | |
| Completed |
NCT01446770 -
Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181
|
Phase 2 | |
| Recruiting |
NCT06138964 -
Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
|
Phase 3 | |
| Enrolling by invitation |
NCT05461157 -
Preoperative Silicone Ointment and Wound Healing
|
N/A | |
| Active, not recruiting |
NCT04988022 -
Dupilumab in the Treatment of Keloids
|
Phase 4 | |
| Withdrawn |
NCT02546076 -
Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars
|
Phase 2 | |
| Completed |
NCT02340325 -
FS2 Safety and Tolerability Study in Healthy Volunteers
|
Phase 1 |