Keloid Clinical Trial
Official title:
Efficacy of Intralesional Triamcinolone and 8% Topical Pirfenidone for Treatment of Keloid Scars: 3-arm Trial
The aim of the study is to assess the efficacy and safety of the combination of intralesional triamcinolone (at doses of 4mg / cm2 at intervals of 4 weeks) and topical pirfenidone 8% (every 8 hours continuously) compared with their isolated application, in the treatment of keloid scars in adults. The duration of this three-arm clinical trial will be 12 months, a 6-month period for treatment and a follow-up of 6 months to assess recurrences. The estimated number of persons to be recruited and randomized for the study is 102.
Individuals with keloid scars will be randomized to 3 arms of treatment in order to assess the efficacy of combining intralesional triamcinolone and topical pirfenidone compared with the isolated application of these drugs. The interventions will last 6 months but the individuals will be assessed monthly to determine recurrences for 6 more months. The scar size will be measure at weeks 12, 24 and 52. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02923596 -
Retrospective Study of Keloid Disorder
|
N/A | |
| Completed |
NCT02922972 -
Treatment of Keloid Scar by Autologous Platelet Rich Plasma Obtained With RgenKit-BCT
|
N/A | |
| Terminated |
NCT01478243 -
Study of Psycho-Social Impact of Keloid
|
N/A | |
| Recruiting |
NCT01423383 -
Epidemiology Study of Keloid
|
N/A | |
| Completed |
NCT03228693 -
Gene Expression and Biomarker Profiling of Keloid Skin
|
N/A | |
| Not yet recruiting |
NCT04326959 -
Implantation of Mesenchymal Stem Cell, Conditioned Medium, or Triamcinolone Acetonide for Keloid
|
Phase 1/Phase 2 | |
| Recruiting |
NCT03312166 -
Compressive Device to Prevent Keloïd Scars Recurrence [SCARWARS]
|
N/A | |
| Recruiting |
NCT04597060 -
The Safety and Efficacy of Thermo-mechanical System for Fractional Ablation Associated Triamcinolone Acetonide Drug Delivery for the Treatment of Hypertrophic Scars and Keloids
|
N/A | |
| Completed |
NCT05939817 -
The Effect of Intralesian Injection of Umbilical Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide on Type 1:3 Collagen Ratio and Interleukin-10 Levels in Keloid: A Randomised Controlled Trial
|
Phase 4 | |
| Completed |
NCT05887804 -
Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial
|
Phase 4 | |
| Completed |
NCT03630198 -
Pain Outcomes Following Intralesional Corticosteroid Injections
|
Phase 4 | |
| Completed |
NCT04169438 -
Pilot Study Investigating a Restorative Wound Care Cream Together With Petrolatum on Surgical Excisions
|
N/A | |
| Recruiting |
NCT01423981 -
Web Based Investigation of Natural History of Keloid Disorder, an Online Survey
|
N/A | |
| Completed |
NCT01446770 -
Evaluation of the Initial Safety and Efficacy of Keloid Lesions Treated With MF-4181
|
Phase 2 | |
| Recruiting |
NCT06138964 -
Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
|
Phase 3 | |
| Enrolling by invitation |
NCT05461157 -
Preoperative Silicone Ointment and Wound Healing
|
N/A | |
| Not yet recruiting |
NCT04593706 -
Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)
|
N/A | |
| Enrolling by invitation |
NCT04988022 -
Dupilumab in the Treatment of Keloids
|
Phase 4 | |
| Withdrawn |
NCT02546076 -
Comparison of Dual-mode ER:YAG Laser in Patients With Long Keloid/Hypertrophic Scars
|
Phase 2 | |
| Completed |
NCT02340325 -
FS2 Safety and Tolerability Study in Healthy Volunteers
|
Phase 1 |