Rheumatic Heart Disease Clinical Trial
Official title:
Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda
The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.
ADUNU is a non-randomized experiment, testing a strategy for implementing an evidence-based practice, decentralized RHD preventive services. The objectives of the study are to: Objective 1: Demonstrate the impact of ADUNU, using the RE-AIM framework to assess program Reach, Effectiveness, Adoption, Implementation and Maintenance. Objective 2: Estimate the cost-effectiveness and budget impact of ADUNU. ADUNU is a public health initiative that will be deployed the Uganda ministry of health in partnership with the District Health Offices (DHO) in two districts. The program will be overseen by the Technical and Quality Assurance (TAQA). ADUNU's main components will include a RHD testing program which consists of community and facility based echocardiographic screening of children and young adults and a registry based secondary prophylaxis injections of Benzathine penicillin G (BPG) at local health centers III and IVs in both districts. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05991219 -
Screening and Secondary Prevention Rheumatic Heart Disease Study
|
||
Completed |
NCT02661763 -
Rheumatic Heart Disease Study in Lusaka
|
N/A | |
Completed |
NCT02188862 -
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region
|
N/A | |
Completed |
NCT01178710 -
Effect of Simvastatin on Cardiac Function
|
N/A | |
Recruiting |
NCT05693545 -
GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial
|
Phase 2 | |
Completed |
NCT06150274 -
Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy
|
N/A | |
Terminated |
NCT03926156 -
RIvoraxaban in Mitral Stenosis
|
Phase 3 | |
Completed |
NCT02474108 -
Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement
|
N/A | |
Recruiting |
NCT04556188 -
The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa
|
||
Recruiting |
NCT03991910 -
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients
|
Phase 3 | |
Active, not recruiting |
NCT03346525 -
Determining the Impact of Penicillin in Latent RHD: The GOAL Trial
|
Phase 2 | |
Recruiting |
NCT05504928 -
Effectiveness of a School-centered Prevention Program on Prevalence of Latent Rheumatic Heart Disease
|
N/A | |
Not yet recruiting |
NCT03549052 -
Right Ventricular Echo Assessment in Mitral Valve Replacement
|
||
Recruiting |
NCT05487469 -
Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass
|
N/A | |
Completed |
NCT05276999 -
Rheumatic Heart Disease Community Streptococcal Treatment Program "RESET"
|
N/A | |
Completed |
NCT05668611 -
Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System
|
N/A | |
Active, not recruiting |
NCT05211024 -
A Long-term Follow up Study for Patients Who Participated in the GOAL Trial (GOAL-Post)
|
||
Withdrawn |
NCT02832531 -
INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority
|
Phase 3 | |
Completed |
NCT01794884 -
Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery
|
Phase 2 | |
Completed |
NCT00264524 -
DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease
|
N/A |