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Clinical Trial Summary

GOAL-Post is comprised of two studies that will help refine recommendations for the duration of secondary prophylaxis for children diagnosed with latent RHD, which is currently not known


Clinical Trial Description

GOAL-Post is comprised of two studies that will help refine recommendations for the duration of secondary prophylaxis for children diagnosed with latent RHD, which is currently not known. Aim 1: Compare the two-year risk of developing RHD (borderline or definite) between children and adolescents who completed the GOAL Trial with a normal echocardiogram (prior diagnosis of latent RHD) and age/sex/and geographically matched controls with repeated normal echocardiograms (normal in both the original GOAL screening in 2017/2018 and in the planned GOAL-Post screening in 2021). Aim 2: Determine the five-year rate of RHD progression and regression among children with persistent latent RHD who receive secondary antibiotic prophylaxis (medium-term impact of prophylaxis). Five years includes time from initial GOAL enrollment to the end of GOAL-Post. Aim 3: Create a RHD biobank that will support further research on RHD genetic susceptibility and pathophysiology ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05211024
Study type Observational
Source Children's Hospital Medical Center, Cincinnati
Contact ndate fall, MS RN
Phone 15135171327
Email [email protected]
Status Recruiting
Phase
Start date January 28, 2022
Completion date June 2024

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