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Cerebral and Circulatory Effects of Neonatal Volume Targeted Ventilation

Respiratory Failure Clinical Trial

Official title:
Cerebral Oxygenation and Circulatory Parameters During Pressure Controlled vs. Volume Targeted Mechanical Ventilation in the Extremely Preterm Infants With Respiratory Distress Syndrome

Clinical Trial Summary

The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.

Clinical Trial Description

Prospective, cross-over trial enrolling neonates <28 weeks' gestation requiring MV. Patients were ventilated for 3 hours with pressure controlled assist-control (PC-AC) mode, followed by 3-hours of volume guarantee assist-control ventilation (VG-AC). Continuous monitoring was carried out using pulse oximetry (oxygen saturation - SpO2 and heart rate - HR), near-infrared spectroscopy (cerebral oxygenation - StO2) and electrical cardiometry (circulatory parameters). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04391634
Study type Interventional
Source Poznan University of Medical Sciences
Contact
Status Completed
Phase N/A
Start date August 1, 2017
Completion date May 30, 2018
View Details
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