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Respiratory Failure clinical trials

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NCT ID: NCT03770208 Not yet recruiting - Respiratory Failure Clinical Trials

RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)

RIB PAIN
Start date: January 31, 2019
Phase: N/A
Study type: Interventional

Traumatic rib fractures (RF) are a relatively common occurrence in patients of all ages, with a 10% incidence in all trauma patients and are associated with significant morbidity and mortality. Adequate analgesia is paramount for preventing pulmonary complications and can reduce morbidity and mortality. There is longstanding evidence of lidocaine's effectiveness and safety in the post-operative patient and the investigators hypothesize that this modality may prove to be ideal in trauma patients with RF. Therefore, it is imperative that intravenous lidocaine be investigated to ascertain if there is significant benefit for pain reduction in patients who have sustained rib fractures. A single-centre, double-blind, randomized control trial to evaluate the analgesic efficacy of a 72-96 hour IV lidocaine infusion plus standard analgesics versus placebo infusion plus standard analgesics will be performed on patients (age 18 or older) diagnosed with two or more traumatic rib fractures ,from blunt thoracic trauma, requiring hospital admission at Victoria Hospital. The primary outcome is mean pain score, as measured on the Visual Analog Scale (VAS). Secondary outcomes are protocol adherence, patient satisfaction as measured on the VAS, incidence of respiratory failure requiring mechanical ventilation, hospital length of stay, ICU length of stay, mortality, incidence of lidocaine toxicity, treatment regimens (use of additional non-opioid analgesics) and total morphine equivalents used (including breakthrough doses). This trial will serve to quantify the analgesic efficacy of intravenous lidocaine for patients with traumatic rib fractures. Successful completion of a single centre trial will inform the development of a multi-centre trial powered to demonstrate a reduction in respiratory failure in the trauma population.

NCT ID: NCT03768232 Not yet recruiting - Respiratory Failure Clinical Trials

Ventilator Induced Diaphragm Dysfunction in Pediatric Critically Ill Patients (VIDD)

VIDD
Start date: January 1, 2019
Phase:
Study type: Observational

evaluation of diaphragmatic disfunction eventually occurred in pediatric patient undergoing mechanical ventilation therapy

NCT ID: NCT03753412 Not yet recruiting - Respiratory Failure Clinical Trials

Recovery From ICUAW Following Severe Respiratory and Cardiac Failure

CLEVERER
Start date: January 1, 2019
Phase:
Study type: Observational

To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.

NCT ID: NCT03744169 Not yet recruiting - Respiratory Failure Clinical Trials

Use of Lung Ultrasound to Diagnose the Etiology of Respiratory Failure in a PICU.

Start date: December 1, 2018
Phase:
Study type: Observational

Respiratory failure is one of the most common conditions requiring admission to the pediatric intensive care unit(PICU). As such, chest radiography has emerged as the most commonly utilized tool in the assessment of lung pathology despite evidence that it may not be the most accurate. Since the seminal article by Lichtenstein in 2007, lung ultrasound has emerged as an alternative to chest radiography in the assessment of critically ill adults. Likewise, pediatric lung ultrasound has a growing body of research to support its use in commonly encountered lung pathology including pneumonia, asthma, bronchiolitis, acute chest syndrome, pleural effusions, and pneumothorax. Despite the rapidly growing body evidence, there remains no literature to support its use in other commonly encountered conditions including, foreign body aspiration, pulmonary edema/acute respiratory distress syndrome, or acute respiratory failure, and despite its growing use, it remains an unstudied tool in the PICU. In the proposed study, we will evaluate whether point-of-care lung ultrasound is accurate in determining the etiology of acute respiratory failure on admission to the PICU. Specifically we aim: 1. To determine the sensitivity and specificity of point-of-care lung ultrasound examination in identifying the etiology of acute pediatric respiratory failure on admission to the PICU. 2. To determine the inter-observer reliability of point-of-care lung ultrasound examination findings in acute pediatric respiratory failure among trainee and expert sonographers. 3. Compare point-of-care lung ultrasound with chest radiography in the rate of detection of pneumothorax and pleural effusion.

NCT ID: NCT03742167 Enrolling by invitation - Respiratory Failure Clinical Trials

Simulation RCT of Telemedical Support for Paramedics

Start date: December 2018
Phase: N/A
Study type: Interventional

This study evaluates the impact of video communication via telemedicine on the quality of emergency care provided to children by paramedic teams supported by a remote physician in a simulated out-of-hospital setting. Half of the paramedic teams will use a video telemedicine platform for communication with a physician, while the other half will use an audio-only platform.

NCT ID: NCT03728491 Not yet recruiting - Respiratory Failure Clinical Trials

Education and Training Competences in Thoracic Ultrasound

Start date: October 31, 2018
Phase: N/A
Study type: Interventional

The use of thoracic ultrasound has expanded widely within the las couple of years, and several studies have proved a high diagnostic accuracy for many of the most common causes of respiratory failure and dyspnoea. The ultrasound scan is a bed-side, and dynamic examination, which demands sufficient theoretical and practical knowledge and competence by the operator, but so far, no studies have explored the effect of simulation-based training for gaining adequate competence compared to traditional hands-on training on healthy figurants. The aim of this study is to examine whether TUS training on a simulator is superior to training on healthy figurants. Secondly, to examine whether the choice of hands-on training has an effect on the number of examinations performed by the trainees from baseline to 4 months follow-up.

NCT ID: NCT03724643 Completed - Respiratory Failure Clinical Trials

Protocolized Ventilator Weaning Verses Usual Care

Start date: October 18, 2007
Phase: N/A
Study type: Interventional

Protocol-driven ventilator weaning strategies utilizing spontaneous breathing trials (SBT) reportedly result in shorter intubation duration and intensive care unit (ICU) length-of-stay (LOS). Investigators compared respiratory therapy (RT)-driven protocolized ventilator weaning (PW) verses usual care (UC) as it pertains to physiologic respiratory parameters, intubation duration, extubation success/reintubation rates, and ICU LOS. The study was a prospective multicenter randomized controlled trial in 6 ICUs at 6 academic-affiliated hospitals in a resource limited setting. Extubation readiness was determined by the attending physician (UC) or the respiratory therapist (PW) using pre-defined criteria and SBT. Physiologic variables, serial blood gas measurements, and weaning indices were assessed including rapid shallow breathing index (RSBI), negative inspiratory force (NIF), occlusion pressure (P0.1), dynamic and static compliance (Cdyn and Cs).

NCT ID: NCT03721237 Recruiting - Respiratory Failure Clinical Trials

Esophageal Balloon Calibration in Assisted Ventilation Mode

EBC-PSV+Sigh
Start date: November 15, 2018
Phase: N/A
Study type: Interventional

Esophageal balloon calibration (EBC) has been proposed during controlled mechanical ventilation in intubated patients in order to optimize esophageal pressure (Pes) signal. Actually, at our knowledge, no data exist about EBC during assisted ventilatory modes such as Pressure Support Ventilation (PSV). The primary endpoint of the present investigation is to assess the feasibility of EBC during PSV and PSV plus Sigh.

NCT ID: NCT03696563 Not yet recruiting - COPD Clinical Trials

FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS

Start date: October 2018
Phase: N/A
Study type: Interventional

Evaluation of automated oxygen titration in comparison with manual adjustment in ambulance.

NCT ID: NCT03682874 Not yet recruiting - Delirium Clinical Trials

Identifying Novel Aging Targets for Treatment of Delirium

INNOVATE
Start date: January 2019
Phase:
Study type: Observational

The long-term goal of this research program is to improve understanding of the mechanistic link between Alzheimer's disease (AD) neuropathology, acute delirium, and cognitive impairment following acute respiratory failure. In this pilot study, the study team will establish a prospective cohort of older patients with acute respiratory failure and obtain data on delirium duration, AD imaging and CSF biomarkers, and cognitive outcomes following critical illness.