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Radical Prostatectomy clinical trials

View clinical trials related to Radical Prostatectomy.

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NCT ID: NCT06351579 Not yet recruiting - Clinical trials for Stress Urinary Incontinence

Data Collection Post Radical Prostatectomy

ALTO
Start date: June 15, 2024
Phase:
Study type: Observational

The study is to collect information on patients undergoing radical prostatectomy (RP), with a primary focus on the occurrence, duration, and severity of post-prostatectomy incontinence. Data will be collected at multiple time points, allowing for a dynamic understanding of urinary incontinence patterns at post RP.

NCT ID: NCT06275945 Recruiting - Clinical trials for Stress Urinary Incontinence

Feasibility Study of A VoRo UrologIc ScaffolD (ARID)

ARID
Start date: April 3, 2023
Phase: Phase 2
Study type: Interventional

The objective of this study is to evaluate the safety and performance of the Voro Urologic Scaffold as a prophylactic treatment for post-prostatectomy stress urinary incontinence. The study is a prospective, multicenter, single arm study. Up to 40 subjects will be treated at up to 3 investigational sites in Panama. Subjects will be followed up post-treatment at catheter removal, 6 weeks post prostatectomy, 3 months, 6 months, 12 months and 2 years.

NCT ID: NCT06085664 Recruiting - Prostate Cancer Clinical Trials

A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy

Start date: December 4, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

To learn about the safety and effects of a drug called REGN5678 when it is given to patients with high-risk prostate cancer.

NCT ID: NCT05625048 Recruiting - Clinical trials for Incontinence, Urinary

Urinary Incontinence After Radical Prostatectomy

Start date: October 12, 2022
Phase: N/A
Study type: Interventional

The aims of this project are; 1) To examine the efficacy of ultrasound-guided pelvic floor muscle training compared to standard care on urinary incontinence in patients undergoing robot assisted radical prostatectomy and 2) To compare physical function, incontinence, and QoL in two groups of patients with low or high function of the pelvic floor muscles respectively before the surgery. This study consists of two parts. The first part is a randomized controlled trial where 44 patients with weak pelvic floor muscle function are randomized to either treatment as usual (control group 1) or ultrasound-guided pelvic floor muscle training (Intervention group). In the second part the patients in control group 1 will be compared with 22 patients with normal/strong pelvic floor muscle function (control group 2). Patients not able to perform the pelvic floor muscle test consisting of 8 repetitions of 4-seconds pelvic floor muscle contraction and 1 repetition of 15-seconds pelvic floor muscle contraction will be randomized to either intervention group or control group 1. Patients able to perform the pelvic floor muscle test will be included in control group 2.

NCT ID: NCT05558007 Recruiting - Prostate Cancer Clinical Trials

Safety and Efficacy Evaluation of BZ371A Topically Applied on Prostatectomized Patients

Start date: November 22, 2023
Phase: Phase 2
Study type: Interventional

To determine efficacy, safety and tolerabiltiy of topically applied BZ371A in patients that experienced RP, in combination with daily tadalafil compared to placebo.

NCT ID: NCT05332340 Completed - Prostate Cancer Clinical Trials

Safety, Tolerability and Pharmacokinetics (PK) Evaluation of BZ371A, Topically Administered

Start date: November 16, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate pharmacokinetics, safety and tolerability profile of BZ371A topically administered in healthy patients.

NCT ID: NCT04862533 Completed - Prostate Cancer Clinical Trials

Effect of Beta-alanine and Pelvic Floor Muscle Training on Urinary Incontinence After Radical Prostatectomy (BELA)

BELA
Start date: February 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of beta-alanine in combination with pelvic floor muscle training (PFMT) compared to PFMT plus placebo in men undergoing radical prostatectomy.

NCT ID: NCT04687969 Recruiting - Prostate Cancer Clinical Trials

Multimodal Machine Learning Characterization of Solid Tumors

Start date: October 23, 2022
Phase:
Study type: Observational

This research study wants to develop advanced imaging methods to more accurately characterize prostate cancer or solid tumor aggressiveness. This observational study involves [18F]DCFPyL positron emission tomography and magnetic resonance imaging (PET/MRI)

NCT ID: NCT04587505 Completed - Quality of Life Clinical Trials

Effect of Epidural Anesthesia and Analgesia on Quality of Recovery After Radical Prostatectomy.

QoR
Start date: April 1, 2019
Phase: Phase 4
Study type: Interventional

Postoperative quality of recovery (QoR) could be related to anesthesia and postoperative analgesia. This study is exploring early QoR after radical prostatectomy in the two groups of anesthesia. The first group had a light general anesthesia with lumbal epidural anesthesia and postoperative epidural analgesia with morphine and ropivacaine. The second group had general anesthesia and a continuous postoperative analgesia with tramadol. The postoperative QoR was evaluated 24 hours after surgery.

NCT ID: NCT04399876 Enrolling by invitation - Prostate Cancer Clinical Trials

Pilot Study of an Implantable Microdevice for Evaluating Drug Responses in Situ in Prostate Cancer

Start date: June 22, 2020
Phase: Phase 1
Study type: Interventional

In this research study, is assessing the feasibility of using an MR-guided implantable microdevice to measure tumor response to chemotherapy and other clinically relevant drugs in participants that have prostate cancer and are scheduled for a radical prostatectomy. The name of the study intervention involved in this study is: - Implantation of a MR-guided microdevice