Quality of Life Clinical Trial
Official title:
Comparison of Long-term Survival and Quality of Life After Minimally Invasive Esophagectomy Versus Open Esophagectomy for Esophageal Cancer: a Retrospective Cohort Study
To analyze and compare the long-term recurrence-free survival rate, overall survival rate and quality of survival after minimally invasive esophagectomy and open esophagectomy, and to conduct subgroup analysis according to the type of esophageal cancer and pathological stage, etc., and to explore more deeply the differences between minimally invasive esophagectomy and open esophagectomy in terms of the benefits for different types of patients, so as to provide reference for the selection of the clinical surgical methods. We will also use the available data to analyze the influence of other factors on patients' long-term survival after surgery.
Status | Not yet recruiting |
Enrollment | 1474 |
Est. completion date | August 31, 2026 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: 1. Patients who had undergone esophageal cancer resection at the Department of Thoracic Surgery, Qilu Hospital, Shandong University, between 2013 and 2021, with pathology results confirming esophageal squamous carcinoma, adenocarcinoma, or other malignant tumors. 2. The surgery was successfully completed, the patient was safely discharged from the hospital, the postoperative follow-up was successful, and if the follow-up patient died, his or her death was due to natural causes. Exclusion Criteria: Perioperative patient deaths, pathologic findings other than those listed above, loss of visits, and postoperative unnatural deaths. |
Country | Name | City | State |
---|---|---|---|
China | Qilu Hospital of Shandong University | Ji'nan | Shandong |
Lead Sponsor | Collaborator |
---|---|
Qilu Hospital of Shandong University |
China,
Chen HS, Lin CH, Wu SC, Wang BY. Comparing survival between neoadjuvant chemoradiotherapy followed by open or thoracoscopic oesophagectomy in patients with oesophageal squamous cell carcinoma. Eur J Cardiothorac Surg. 2022 Jul 11;62(2):ezac114. doi: 10.1093/ejcts/ezac114. — View Citation
Giulini L, Dubecz A. Minimally invasive versus open oesophagectomy for cancer: propensity score analysis improves results' reliability but matching criteria need to be selected accurately. Eur J Cardiothorac Surg. 2022 Jul 11;62(2):ezac192. doi: 10.1093/ejcts/ezac192. No abstract available. — View Citation
Gottlieb-Vedi E, Kauppila JH, Mattsson F, Lindblad M, Nilsson M, Lagergren P, Rouvelas I, Lagergren J; FINEGO group. Long-term Survival in Esophageal Cancer After Minimally Invasive Esophagectomy Compared to Open Esophagectomy. Ann Surg. 2022 Dec 1;276(6):e744-e748. doi: 10.1097/SLA.0000000000004645. Epub 2021 Jan 20. — View Citation
Ising MS, Smith SA, Trivedi JR, Martin RCG, Phillips P, Van Berkel V, Fox MP. Minimally Invasive Esophagectomy Is Associated with Superior Survival Compared to Open Surgery. Am Surg. 2023 May;89(5):1833-1843. doi: 10.1177/00031348221078962. Epub 2022 Mar 23. — View Citation
Knitter S, Andreou A, Hofmann T, Chopra S, Denecke C, Thuss-Patience PC, Kroll D, Bahra M, Schmelzle M, Pratschke J, Biebl M. Minimally Invasive Versus Open Ivor-Lewis Esophagectomy for Esophageal Cancer or Cancer of the Gastroesophageal Junction: Comparison of Postoperative Outcomes and Long-term Survival Using Propensity Score Matching Analysis. Anticancer Res. 2021 Jul;41(7):3499-3510. doi: 10.21873/anticanres.15137. — View Citation
Li Z, Liu C, Liu Y, Yao S, Xu B, Dong G. Comparisons between minimally invasive and open esophagectomy for esophageal cancer with cervical anastomosis: a retrospective study. J Cardiothorac Surg. 2020 Jun 8;15(1):128. doi: 10.1186/s13019-020-01182-3. — View Citation
van der Sluis PC, van der Horst S, May AM, Schippers C, Brosens LAA, Joore HCA, Kroese CC, Haj Mohammad N, Mook S, Vleggaar FP, Borel Rinkes IHM, Ruurda JP, van Hillegersberg R. Robot-assisted Minimally Invasive Thoracolaparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy for Resectable Esophageal Cancer: A Randomized Controlled Trial. Ann Surg. 2019 Apr;269(4):621-630. doi: 10.1097/SLA.0000000000003031. — View Citation
Zheng Y, Li Y, Liu X, Sun H, Shen S, Ba Y, Wang Z, Liu S, Xing W. Minimally Invasive Versus Open McKeown for Patients with Esophageal Cancer: A Retrospective Study. Ann Surg Oncol. 2021 Oct;28(11):6329-6336. doi: 10.1245/s10434-021-10105-y. Epub 2021 May 13. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Survival Information | Dead or alive 5 years after surgery | From enrollment to 5 years after surgery | |
Primary | score of Quality of life | Measured with EORTC QLQ-OES18 Quality of Life Questionnaire | From enrollment to 5 years after surgery | |
Secondary | Recurrence or metastasis | Imaging, lab results | From enrollment to 5 years after surgery |
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