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Pulmonary Valve Insufficiency clinical trials

View clinical trials related to Pulmonary Valve Insufficiency.

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NCT ID: NCT05379309 Completed - Clinical trials for Respiratory Insufficiency

Compliance in Non Invasive Mechanical Ventilation

Start date: August 1, 2017
Phase:
Study type: Observational

Database study of the adherence to treatment to non-invasive mechanical ventilation

NCT ID: NCT05090228 Completed - Clinical trials for Pulmonary Valve Insufficiency

Right Ventricle Remodeling After Pulmonary Valve Replacement and Percutaneous Pulmonary Valve Insertion

RV-REPAIR
Start date: February 1, 2016
Phase:
Study type: Observational

This study investigates damage of the right cardiac chamber in adult patients with a congenital heart defect involving the pulmonary valve (the heart valve between the right cardiac chamber and the lungs). The investigators want to investigate if novel, less invasive techniques are feasible to assess damage of this right cardiac chamber, to improve follow-up and timing of intervention (valve replacement) in this group of patients.

NCT ID: NCT04965844 Completed - Clinical trials for Respiratory Insufficiency

Closed-loop Oxygen Control for High Flow Nasal Therapy

HILOOP
Start date: April 27, 2021
Phase: N/A
Study type: Interventional

In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decrease work of breathing as compared to standard oxygen therapy by facemask. Current guidelines recommend adjusting oxygen flow rates to keep the oxygen saturation measured by pulse oximetry (SpO2) in the target range and avoid hypoxemia and hyperoxemia. The hypothesis of the study is that closed loop oxygen control increases the time spent within clinically targeted SpO2 ranges and decreases the time spent outside clinical target SpO2 ranges as compared to manual oxygen control in ICU patients treated with HFNT.

NCT ID: NCT04630743 Completed - Heart Failure Clinical Trials

Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease

CoBeMEB
Start date: February 9, 2019
Phase: N/A
Study type: Interventional

Episodic breathlessness is a common and distressing symptom in patients with advanced disease such as cancer, chronic obstructive pulmonary disease (COPD) and chronic heart failure. Since the short duration of the majority of breathless episodes limits the effectiveness of pharmacological interventions (e.g. opioids), non-pharmacological management strategies play a major role. As non-pharmacological strategies patients use, for example, cognitive and behavioural methods such as breathing or relaxation techniques. The aim of the study is to test a brief cognitive and behavioural intervention for an improved management of episodic breathlessness. Initially, a Delphi procedure with international experts has been used to develop the brief intervention consisting of various non-pharmacological strategies to enhance the management of breathless episodes. In the single-arm therapeutic exploratory trial (phase II), the feasibility and potential effects of the brief intervention, such as patient-reported breathlessness mastery, episodic breathlessness characteristics, quality of life, symptom burden, caregivers' burden, and breathlessness in general will be examined. The results of the study form the basis for planning and implementing a subsequent confirmatory randomized control trial (phase III).

NCT ID: NCT04412356 Completed - Covid-19 Clinical Trials

Timing of Tracheotomy in Covid-19 Patients

TTCOV19
Start date: June 6, 2020
Phase: N/A
Study type: Interventional

Critically ill covid-19 patients may require respiratory support including mechanical ventilation. After an initial period with an endotracheal tube, a tracheotomy is performed in order to reduce potential airway complications, reduce the need of sedation and facilitate the monitoring and recovery. The optimal timing of this surgical procedure is, however, still unknown. The aim of this randomized, controlled trial is to compare the outcome of early (within 7 days after intubation) vs late (at least 10 days after intubation) tracheotomy in covid-19 patients. The need for mechanical ventilation, sedation, additional oxygen support, frequency of complications, duration at the ICU and mortality through the ICU stay will be evaluated and compared.

NCT ID: NCT04395144 Completed - Respiratory Failure Clinical Trials

COVid-19: Awake Proning and High-flow Nasal Cannula in respiratorY DistrEss

COVAYDE
Start date: May 15, 2020
Phase: N/A
Study type: Interventional

Prone positioning is an established intervention in mechanically ventilated acute respiratory distress syndrome (ARDS) patients, with demonstrated reductions in mortality. Preliminary data suggest that awake proning in patients with COVID-19 treated with high-flow nasal oxygenation (HFNO) improves gas exchanges, and might be associated with a reduced need of mechanical ventilation, and reduced mortality. Further investigation in a formal randomized-controlled trial is need.

NCT ID: NCT04368325 Completed - Muscle Weakness Clinical Trials

Low Creatinine Level and Respiratory Failure

Start date: May 17, 2015
Phase:
Study type: Observational [Patient Registry]

Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients. The investigators compared the outcomes of participants with low creatinine levels with subsequent ICU participants admitted into ICU in the tertiary hospital.

NCT ID: NCT04346693 Completed - Pneumonia Clinical Trials

An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19

Start date: April 8, 2020
Phase: Phase 3
Study type: Interventional

The purpose of the study is to evaluate an effectiveness of the drug Dalargin in combination with Leitragin for the prevention and treatment of severe pulmonary complications symptoms associated with severe and critical coronavirus infection cases (SARS COVID19, expanded as Severe acute respiratory syndrome Cоrona Virus Disease 2019 ). Test drugs that will be administered to patients are: - Leitragin, solution for inhalation administration, - Dalargin, solution for intravenous and intramuscular administration.

NCT ID: NCT04118725 Completed - Systemic Sclerosis Clinical Trials

Muscular Respiratory Involvement and Systemic Sclerosis

SIROCO
Start date: October 21, 2019
Phase: N/A
Study type: Interventional

Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors. Diffuse fibrosing myopathy of bad prognosis have been reported in ScS.To now, muscular respiratory involvement has not been evaluated in ScS. Therefore, ScS patients (with or without dyspnea) could have underlying respiratory muscular involvement not detected by current standard of care with pulmonary function tests (PFT). This project is the first, to the best of our knowledge, to assess frequency of respiratory muscular involvement in ScS and to evaluate a screening strategy of this involvement.

NCT ID: NCT04115969 Completed - Clinical trials for Respiratory Insufficiency

Outcome After Non-invasive Ventilation.

Start date: October 4, 2019
Phase:
Study type: Observational

The study is an exploratory retrospective observational study with the aim to describe outcome fo the cohort of patients that receive non-invasive ventilation at an intensive care unit. Main research questions are: - Characteristics of the cohort. - The course for the patients at the ICU. - ICU-mortality and 30-day mortality - Amount of patients with limitations of care. - Factors associated with mortality.