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Safety and Effectiveness of Cyclosporin in the Management of COVID19 ARDS Patients in Alexandria University Hospital

Pulmonary Fibrosis Clinical Trial

Official title:
Safety and Therapeutic Efficacy of Cyclosporine Plus Standard of Care Treatment on ARDS in COVID -19 Patients at Alexandria University Hospitals in 2021: a Comparative Study

Clinical Trial Summary

The study to evaluate the effect of cyclosporine ( IL2 inhibitor and antiviral) verse standard care treatment on decrease ADRS, hyper inflammation, hypercytokinemia, and the mortality rate

Clinical Trial Description

To test the efficacy of IL-2 inhibitors (Cyclosporine) compared to the Standard of care according to hospital protocol on COVID-19 patients concerning the clinical outcome (cytokines level, clinical improvement, and PCR of SARS-CoV-2 through the study period). AIM: The slow progression of the disease, improving survival among COVID-19 patients, and Standard assessment of patient improvement. - Standard assessment of patient improvement: - PCR-SARS-CoV-2 negative - No fever - No cytopenia (Hb ≥90 g/L, ANC ≥0.5x109/L, platelets ≥100x109/L) • - No hyperferritinemia ≥500 μg/L - (Decrease of IL2) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04979884
Study type Interventional
Source Alexandria University
Contact
Status Completed
Phase Phase 3
Start date January 3, 2022
Completion date December 9, 2022
View Details
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