The Oscillation of Crystalline & Intraocular Lenses

Status Not yet recruiting

Clinical Trial Summary

The crystalline lens of the human eye helps to sharpen vision. There can be issues with the support/stability of the lens. This could be seen with the naked eye of an external observer or with the use of a slit lamp.

Certain eye conditions can predispose to issues with lens stability. If patients have stability issues with their natural lens- this would be termed as "phakodonesis". However, in patients who have had prior cataract surgery with implantation of an artificial lens (IOL)- this would be termed as "pseudophakodonesis". Eye conditions such as pseudoexfoliation or Marfan-syndrome can lead to unstable lens support- this can be detected if there are advanced stability issues.

However, small instability in the eye's would not be detected with present descriptive methods. The authors have designed a high-speed camera which is able to detect stability of the lens, especially during eye movements. The high-speed camera can detect variation in the change of light reflex from the lens and calculate the amount of lens instability/oscillation. The results (in normal eyes) of this high-speed camera has already been published in a peer-review journal. It is non-contact and measures lens movement. The test lasts less than 5 minutes.

Further research is required to assess the amount of lens oscillation (wobbling) in different eye populations - patients with previous cataract surgery (an artificial implant is used to replace the lens) or eye conditions (such as pseudoexfoliation, Marfan syndrome). The amount of lens stability has a role in the planning of further intraocular surgery - especially cataract extraction - however, at present, there is no approved quantitative measurement for this.

Participants will be recruited through Anglia Ruskin University (educational establishment), local community groups, and through Southend University Hospital eye clinics (NHS organisation). Participants' data will remain anonymous.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cataract
Ectopia Lentis
Exfoliation Syndrome
Marfan Syndrome
Marfan's Syndrome With Ocular Manifestations
Phakodonesis
Pseudoexfoliation Syndrome
Syndrome

Clinical Trial Details

NCT number	NCT04274634
Study type	Observational
Source	Anglia Ruskin University
Contact
Status	Not yet recruiting
Phase
Start date	October 2020
Completion date	March 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04685538` - Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification.	Phase 3
Recruiting	`NCT06060041` - IC-8 Apthera IOL New Enrollment Post Approval Study
Recruiting	`NCT05518539` - Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens
Recruiting	`NCT05271942` - Tilt and Tumble vs Divide and Conquer - a Unique Comparison of the Two Cataract Surgery Methods	N/A
Active, not recruiting	`NCT04778501` - PMCF Study on Monofocal Toric IOL (PODEYE TORIC) in Asia	N/A
Completed	`NCT05062564` - Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye	N/A
Completed	`NCT03751033` - Influence of DisCoVisc Ophthalmic Viscosurgical Device (OVD) on Intraoperative Aberrometry Readings	N/A
Completed	`NCT02529488` - Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00	N/A
Completed	`NCT04539548` - A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract	Phase 3
Completed	`NCT03740659` - Evaluation Of Aqueous Humor Of Levofloxacin-Dexamethasone Eye Drops And Of Its Components In Patients Undergoing Cataract Surgery	Phase 2
Completed	`NCT03494257` - Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification	N/A
Completed	`NCT05119127` - Rotational Stability of Acrysof IQ Vivity Extended Vision Toric IOL and Refractive Visual Outcome.	N/A
Active, not recruiting	`NCT04271709` - Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT)	N/A
Recruiting	`NCT03713268` - Intraoperative OCT Guidance of Intraocular Surgery II
Completed	`NCT03739528` - Levo-Dexa vs. Tobra+Dexa for Prevention and Treatment of Inflammation and Prevention of Infection in Cataract Surgery	Phase 3
Completed	`NCT02888210` - A Study Assessing Safety and Efficacy of MD-15 Intraocular Lens in Patients With Aphakic Eye After Cataract Surgery	Phase 3
Completed	`NCT03356847` - Evaluation of the Rotational Stability of the Monofocal SISA Implant Following Cataract Surgery	N/A
Completed	`NCT04332640` - Clinical Evaluation of the Next Generation Phaco System	N/A
Recruiting	`NCT03638726` - Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification	Phase 4
Completed	`NCT03050697` - Evaluation of the Safety and Performance of the HARMONI® Toric Lens	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Oscillation of Crystalline and Intraocular Lenses

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms