Cataract Clinical Trial
Official title:
Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification
This study aims to evaluate the effect of fixed brinzolamide-brimonidine combination on
intaocular pressure after uncomplicated phacoemulsification surgery.
Patients scheduled for phacoemulsification will be randomly assigned to 1 of 2 groups.
The treatment group will receive 1 drop of brimonidine-brinzolamide fixed combination
immediately after surgery, and the control group will receive no treatment. The IOP will be
measured preoperatively and at 6, 12, and 24 hours postoperatively.
Phacoemulsification with the use of an ophthalmic viscosurgical device (OVD) and implantation
of a foldable intraocular lens (IOL) is the preferred technique for cataract surgery today.
OVDs in spite of their advantages in phacoemulsification surgery, have been correlated with
intraocular pressure (IOP) increase within the first 24 hours postoperatively. This
constitutes a frequent short-term complication of cataract surgery and can lead to corneal
edema and pain. This IOP rise may also increase the risk of retinal artery occlusion,
ischemic optic neuropathy, and deterioration of preexisting glaucomatous nerve damage.
DuoVisc, an OVD that consists of Viscoat (chondroitin sulfate 4.0%-sodium hyaluronate 3.0%)
in combination with Provisc (sodium hyaluronate 1.0%) is the most frequently used OVD during
cataract surgery.
To prevent IOP spikes postoperatively, various antiglaucoma agents have been used.
Brinzolamide is a carbonic anhydrase inhibitor that acts upon the ciliary processes and
reduces aqueous humor secretion.Brimonidine is a highly selective a2-adrenergic agonist that
increases uveoscleral outflow and reduces aqueous humor production.
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