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Pruritus clinical trials

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NCT ID: NCT04949893 Completed - Chronic Pruritus Clinical Trials

Causes of Chronic Pruritus

PRURISINE
Start date: May 2, 2019
Phase:
Study type: Observational

The aim of this study is to include all patients followed between 2008 and 2018 in order to analyze the etiologie of the chronic pruritus

NCT ID: NCT04829578 Completed - Clinical trials for Chronic Idiopathic Pruritus

Hypnosis for Chronic Idiopathic Pruritus

Start date: April 13, 2021
Phase: N/A
Study type: Interventional

Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.

NCT ID: NCT04823130 Completed - Dermatitis Atopic Clinical Trials

Dupilumab Effect on Pruritus Neuro-mechanisms in Patients With Atopic Dermatitis

DIFFEREN-STAD
Start date: April 22, 2021
Phase: Phase 4
Study type: Interventional

Primary Objective: - Assess change in neuronal architecture following long term treatment with dupilumab in skin biopsies from atopic dermatitis (AD) participants with chronic pruritus. Secondary Objectives: - Assess change in neuronal architecture following short term treatment with dupilumab and during follow-up in skin biopsies from AD participants with chronic pruritus. - To evaluate the efficacy of dupilumab in AD participants with chronic pruritus. - To evaluate the safety of dupilumab in adult participants with moderate-to-severe AD.

NCT ID: NCT04745429 Completed - Depression Clinical Trials

Non-pharmacological Mitigation of Psoriasis

Start date: February 19, 2020
Phase: N/A
Study type: Interventional

In the past few years, research has provided evidence for a possibility of dampening immune system by one's will after undergoing a specific training program. Aim of this study was to verity the efficacy in affecting both mind and body by assessing psoriasis activity and psychological functioning. Among the members of both of the groups intensity of skin lesions and pruritus were assessed, consultation regarding treatment took place and multiple questionnaires regarding sleep quality, mindfulness and depressive symptoms were distributed. Blood samples were collected to asses intensity of inflammation, including interleukins.

NCT ID: NCT04731389 Completed - Acne Clinical Trials

Digital Strategies for Patients With Chronic Dermatosis With Pruritus / Skin Picking Disorder

Start date: February 1, 2021
Phase: N/A
Study type: Interventional

Almost 35% of patients treated to dermatosis have some psychiatric disorder. The aim of this study is to evaluate the prevalence and severity of skin picking disorder and other dermatosis, and also test the efficacy of an online-delivered cognitive-behavioral therapy to improve skin picking disorder severity.

NCT ID: NCT04711603 Completed - Uremic Pruritus Clinical Trials

A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus.

Start date: January 16, 2021
Phase: Phase 3
Study type: Interventional

Double-blind, Placebo-controlled study to confirm the superiority of MR13A9 to placebo, and followed by extension, open-label treatment to confirm long-term safety of MA13A9 in hemodialysis patients with pruritus.

NCT ID: NCT04706975 Completed - Pruritus Clinical Trials

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)

Start date: January 11, 2021
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of twice-daily (BID) oral difelikefalin (CR845) in adult subjects with notalgia paresthetica and moderate to severe pruritus.

NCT ID: NCT04693195 Completed - Atopic Dermatitis Clinical Trials

A Multiple-Dose Study of BLU-5937 in Chronic Pruritus Associated With Atopic Dermatitis

BLUEPRINT
Start date: December 9, 2020
Phase: Phase 2
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled, parallel design study of BLU-5937 for the treatment of chronic pruritus in adult subjects with atopic dermatitis (AD).

NCT ID: NCT04639674 Completed - Uremic Pruritus Clinical Trials

AST-120 in Hemodialysis Patients With Uremic Pruritus

AST-120
Start date: July 2, 2020
Phase: Phase 4
Study type: Interventional

The prevalence of cutaneous pruritus among hemodialysis patients is about 50% to 80%. There is only a handful of studies on the itchy skin of hemodialysis patients and the findings are to be validated. Effective drugs to treat cutaneous pruritus are not available yet. Hence, the purpose of the study is to eliminate the uremic toxins from the intestinal tract using AST-120 as a treatment measure to improve the symptom of the hemodialysis patients' cutaneous pruritus and discuss and assess its effectiveness. For this, the investigators will recruit 150 patients to validate the application potential of the AST-120 in the cutaneous pruritus brought about by uremia.

NCT ID: NCT04557644 Completed - Contagious Itch Clinical Trials

Contagious Itch, Disgust and Empathy in Patients and Medical Staff

Start date: September 16, 2020
Phase: N/A
Study type: Interventional

This study is to assess the relationship between CI, disgust and empathy in medical staff treating patients with scabies, to differentiate the impact of visual and verbal stimuli contributing to CI and to assess information about CI, disgust and empathy in a family infested with scabies.