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Dupilumab Effect on Pruritus Neuro-mechanisms in Patients With Atopic Dermatitis — DIFFEREN-STAD  

Dermatitis Atopic Clinical Trial

Official title:
A Multi-center, Exploratory Study to Assess Dupilumab Effect on Pruritus Neuro-mechanisms in Patients With Atopic Dermatitis

Clinical Trial Summary

Primary Objective: - Assess change in neuronal architecture following long term treatment with dupilumab in skin biopsies from atopic dermatitis (AD) participants with chronic pruritus. Secondary Objectives: - Assess change in neuronal architecture following short term treatment with dupilumab and during follow-up in skin biopsies from AD participants with chronic pruritus. - To evaluate the efficacy of dupilumab in AD participants with chronic pruritus. - To evaluate the safety of dupilumab in adult participants with moderate-to-severe AD.

Clinical Trial Description

AD participants: A 20-week Observation Period including 16 weeks of treatment for AD participants and a 4-week follow-up period; Healthy participants: 8 days observation period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04823130
Study type Interventional
Source Sanofi
Contact
Status Completed
Phase Phase 4
Start date April 22, 2021
Completion date August 30, 2022
View Details
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