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Prostatectomy clinical trials

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NCT ID: NCT03618693 Completed - Pain Clinical Trials

Impact of Perioperative Analgesia in Prostatectomy Patients on Early Quality of Recovery (SPITALIDO)

SPITALIDO
Start date: August 13, 2018
Phase: N/A
Study type: Interventional

The rationale behind this RCT is to assess within 24 hours after surgery the quality of recovery of prostatectomy patients treated with 3 different analgesia concepts (intraoperative spinal analgesia, transversus abdominis plane block, intravenous lidocaine administration) using the quality of recovery (QoR) 15 questionnaire.

NCT ID: NCT03607279 Completed - Prostatectomy Clinical Trials

Comparison of Plasma Neutrophil Gelatinase - Associated Lipocalin (NGAL) Levels

Start date: January 2017
Phase:
Study type: Observational [Patient Registry]

The purpose of the study is to compare the effect of two surgical techniques (open vs robotic assisted) on plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) after radical prostatectomy.

NCT ID: NCT03150758 Completed - Prostatectomy Clinical Trials

Intra-operative Assessment of Cavernosal Nerve Stimulus Threshold

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

Erectile dysfunction persists in approximately 80% of men 1 year after prostatectomy. Various erectile rehabilitation strategies have not provided benefit. Electrical stimulation has been demonstrated to benefit neuroregeneration and the functional recovery of neuromuscular systems. Therefore, electrical stimulation of the cavernosal nerves during radical prostatectomy is being investigated for its potential development into a treatment aimed at improving recovery of erectile function after prostatectomy. This pilot study is intended to determine the threshold of electrical stimulation that results in penile erection, as defined by persistent intracavernosal pressure increase, such that future studies of sub-threshold stimulation may be pursued.

NCT ID: NCT03080116 Recruiting - Prostate Cancer Clinical Trials

Neoadjuvant Degarelix With or Without Apalutamide (ARN-509) Followed by Radical Prostatectomy

ARNEO
Start date: March 28, 2019
Phase: Phase 2
Study type: Interventional

RATIONALE: Neoadjuvant hormonal therapy using luteinizing hormone releasing hormone (LHRH) agonists and/or anti-androgens has already demonstrated to downstage primary prostate cancer in patients treated by radical prostatectomy without a survival benefit. There is no evidence yet of a survival impact of LHRH antagonist (LHRHa) +/- new-generation anti-androgens in this setting. Thus novel studies are needed to assess this treatment combination. PURPOSE: To assess the difference in treatment antitumor effect between arms by measuring pathological tumor volume with minimal residual disease (MRD) following radical prostatectomy + pelvic lymph-node dissection (RP + PLND) for intermediate or high-risk prostate cancer patients.

NCT ID: NCT03061760 Not yet recruiting - Prostate Cancer Clinical Trials

Effects of Urinary Bladder Hypertrophy on Urge Urine Incontinence After Radical Prostatectomy

Start date: March 1, 2017
Phase: N/A
Study type: Observational

This study is designed to evaluate men before radical prostatectomy for the incidence of Overactive Bladder (OAB), as well as urge urine incontinence (UUI) development after the surgery. Patients will be evaluated for signs of OAB and for signs of Bladder Outlet Obstruction (BOO). Afterwards they will be divided into four observational groups. Follow up period is designed to be 12 months.

NCT ID: NCT02924974 Completed - Clinical trials for Patient Satisfaction

Spinal Morphine in Robotic Assisted Radical Prostatectomy

SALMON-RARP
Start date: September 2016
Phase: Phase 4
Study type: Interventional

This study will investigate if a single shot of spinal morphine will increase patient satisfaction when compared to intravenous morphine in Robot-Assisted Radical Prostatectomy

NCT ID: NCT02621684 Withdrawn - Prostate Cancer Clinical Trials

Physical Activity Intervention in African American Men After Radical Prostatectomy

Start date: November 2014
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to evaluate the feasibility of recruiting African American prostate cancer survivors to a 12 week physical activity intervention study of three arms (aerobics, resistance training, and usual care) through physician referral and community advertisement strategies. In addition, the investigators will investigate the acceptance rate of the intervention and gather preliminary results on the effect of exercise on African American men's urinary and sexual functions. These data can then be used to refine the intervention and its implementation model, and to inform the submission of a larger grant to the National Institutes of Health.

NCT ID: NCT02485665 Recruiting - Exercise Clinical Trials

Efficacy of Extracorporeal Biofeedback Device for Post-prostatectomy Incontinence

Start date: July 2015
Phase: N/A
Study type: Interventional

To evaluate the efficacy of postoperative pelvic floor muscle training using personalized extracorporeal biofeedback device among patients with post-prostatectomy incontinence

NCT ID: NCT02369211 Completed - Pain Clinical Trials

Pharmacoeconomics and Related Patient Outcomes of Multi-dose Intravenous Acetaminophen (OFIRMEV)

Start date: September 2015
Phase: Phase 4
Study type: Interventional

To examine pharmacoeconomics of IV acetaminophen (Ofirmev). Specifically, to examine its potential to improve hospital efficiency and patient outcomes. The investigators compare the addition of IV acetaminophen versus placebo on postoperative anesthesia care unit recovery times, inpatient hospital length of stay (LOS), postoperative pain scores, consumption of opiates as rescue agents and side effects among patients undergoing robotic-assisted laparoscopic prostatectomy (RALP).

NCT ID: NCT01625572 Completed - Pain Clinical Trials

Ultrasound-assisted Bilateral Transversus Abdominis Plane Block for Open Prostatectomy

TAPPro
Start date: July 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the quality of a transversus abdominis plane blockade with an intravenous pain therapy with opioids. Due to the relatively low side effect profile and comparably few contraindications, this method offers a good option, to be a standard procedure or better alternative in the treatment of pain in surgery of the prostate.