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Prostatectomy clinical trials

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NCT ID: NCT05008900 Recruiting - Prostate Cancer Clinical Trials

Timing of Post-prostatectomy PSMA Imaging

TOPP
Start date: March 22, 2022
Phase: Phase 2
Study type: Interventional

The investigators will randomize patients presenting with early BCR with a negative baseline PSMA PET/CT, to upfront SRT or surveillance. Early BCR is defined as a PSA relapse of >0.1 to <0.3 ng/mL. Patients in the surveillance arm will be monitored with PSA every 3 months. A repeat PSMA PET/CT will be undertaken when the PSA reaches a target level of >0.5 to <1.0 ng/mL. Both early radiation treatment and surveillance with repeat PSMA PET/CT imaging are within patterns of practice locally; therefore, the investigators believe that there is clinical equipoise on this subject.

NCT ID: NCT04992026 Active, not recruiting - Prostatectomy Clinical Trials

The Efficacy and Safety of Prostatectomy for Castration-Naive Oligometastatic Prostate Cancer

Start date: January 1, 2021
Phase: Phase 2
Study type: Interventional

This randomized, controlled, multi-center clinical trial aims to evaluate the efficacy and safety of prostatectomy for castration-Naive oligometastatic prostate cancer

NCT ID: NCT04933084 Recruiting - Clinical trials for Opioid-Related Disorders

Pre-operative Education Modalities to Decrease Opioid Use

Start date: September 16, 2021
Phase: N/A
Study type: Interventional

This is a triple-armed, randomized, controlled, non-blinded trial to study the effect of preoperative patient education in conjunction with a limited opioid peri-operative analgesia program on post-operative opioid use following radical prostatectomy. Patients will be randomized into three education arms: usual care (variable provider-dependent education), text handout, or text handout and pre-recorded video. The impact of patient education on outcomes of in-hospital, post-discharge, and persistent opioid use will be studied.

NCT ID: NCT04404738 Recruiting - Nephrectomy Clinical Trials

MicroPort® Endoscopic Instrument Control System to Accomplish Robotic-assisted Surgery in Urology

MARS
Start date: June 29, 2020
Phase: N/A
Study type: Interventional

Laparoscopy, now virtually completely, was replaced with robotic surgery in uro-oncological surgery in the world. And given the significant increase in the number of robotic surgeries for prostate, bladder and kidney cancer, it is now a major domain in oncological surgery. Microport MedBot Inc. has independently developed a domestic surgical robot in China. Therefore, the purpose of the study is to evaluate the safety and efficacy of the Chinese robot when applied to surgery in oncology.

NCT ID: NCT04261777 Recruiting - Prostate Cancer Clinical Trials

Ferumoxtran-10-enhanced MRI in Prostate Cancer Patients

Start date: May 27, 2020
Phase: Phase 3
Study type: Interventional

This will be a confirmatory, prospective, open-label, single-arm, reader-blinded, multi-centre phase 3 study to assess the diagnostic accuracy and safety of Ferrotran®-enhanced MRI in comparison to unenhanced MRI in the detection of pelvic lymph node metastases in newly-diagnosed adult patients with prostate cancer and an intermediate to high risk for lymph node metastases, based on the D'Amico criteria.

NCT ID: NCT04172519 Active, not recruiting - Clinical trials for Urinary Incontinence

Pelvic Floor Muscles Training After Radical Prostatectomy.

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Prostate cancer (PCa) is a malignant tumor commonly diagnosed among men in the USA and Europe. About 81% of cases of prostate cancer are detected early on, which allows patients to receive effective treatment. High risk cancer patients may undergo radical prostatectomy (RP) which includes the removal of the entire prostate gland together with both seminal vesicles, prostatic urethra, and bilateral pelvic lymph nodes. Even though RP has been improved over decades, patients are still at risk of surgical and post-surgical complications. The most common complications include urinary incontinence and erectile dysfunction. Pelvic floor muscle training is recognized as the physiotherapeutic modality for the treatment of urinary incontinence in men after radical prostatectomy. This method is recommended by the European Association of Urology. However, the literature analysis and systematic review carried out by our team prove that there are relatively few clinical trials with a well-developed research protocol assessing this form of therapy. In order to objectify the effects of therapy, we will assess both psychosocial aspects, as well as try to answer the question whether biochemical parameters can be a marker of pelvic floor muscles. In previous own research, we obtained promising results by examining biochemical parameters during pelvic floor muscle activity in women with stress urinary incontinence.

NCT ID: NCT03884335 Completed - Prostatectomy Clinical Trials

Radical Laparoscopic Prostatectomy. Enhanced Recovery After Surgery (ERAS) Program

Start date: October 1, 2016
Phase: N/A
Study type: Interventional

Current trends are based on the implementation of enhanced recovery programs (ERP) for most surgical procedures. The transversus abdominis plane (TAP) block has been demonstrated as an effective analgesic alternative in abdominal surgeries. The goal of this study was to compare analgesic efficacy of the TAP block against epidural technique in patients who underwent laparoscopic radical prostatectomy (LRP) surgery in an ERP setting. This study was performed between October 2016 and May 2018

NCT ID: NCT03721029 Completed - Clinical trials for Urinary Incontinence

Intraoperative Nerve Monitoring During Robotic-assisted Radical Prostatectomy

Start date: November 21, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate whether the use of intraoperative nerve monitoring during robotic-assisted radical prostatectomy (RARP) can predict and improve post-surgery urinary continence and erectile function.

NCT ID: NCT03714984 Completed - Clinical trials for Pelvic Floor Disorders

The Efficacy of Pre-operative Educational Pelvic Floor Intervention on Urinary Continence

Start date: October 15, 2018
Phase: N/A
Study type: Interventional

Prostate cancer is the most common type of cancer between male population and urinary incontinence (UI) is the most common of long-term sequelae. Nowadays, robotic prostatectomy became the surgery standard but there is still discrepant results regards the incidence of UI and there is a lack of studies about the use of pelvic floor rehabilitation in this population. Our study aims to assesses the efficacy of preoperative educational method in urinary incontinence after robotic prostatectomy.

NCT ID: NCT03624465 Completed - Prostatectomy Clinical Trials

Prospective Clinical Study of the Levita Magnetics Surgical System Used for Prostatectomy Surgery

Start date: August 13, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of the Levita Magnetic Surgical System in patients undergoing prostatectomy surgery.