Clinical Trial Details
— Status: Active, not recruiting
Administrative data
NCT number |
NCT04560725 |
Other study ID # |
2020KT107 |
Secondary ID |
|
Status |
Active, not recruiting |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
October 22, 2020 |
Est. completion date |
December 1, 2024 |
Study information
Verified date |
January 2024 |
Source |
Peking University Cancer Hospital & Institute |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
To study the radioactive uptake of [68Ga]P137 in the lesion sites of PCa patients and
evaluate the ability of [68Ga]P137 to detect PSMA overexpression in PCa patients (especially
those with recurrent or advanced PCa).
Description:
Prostate cancer is the most common malignancy of the male reproductive system.Prostate
specific membrane antigen is a highly specific prostatic epithelial cell membrane antigen,
which is highly expressed in solid tumors such as prostate cancer. More than 90% of prostate
cancer cells express PSMA, so PSMA can be used as an important imaging target for prostate
cancer.Positron emission tomography has the advantages of non-invasive, high resolution and
high sensitivity, etc. The PET tracer based on PSMA radiographic label is developing rapidly,
which is of great significance for the early diagnosis, prognosis and treatment of prostate
cancer.Used for radionuclide 68Ga has a half-life of PET imaging (T1/2 = 68 min) is
appropriate, prepared from 68Ge-68Ga generator, relatively low cost, coordination marking
method is simple, easy to realize automatic synthesis technology and advantages of medicine
preparation, so 68Ga- labeled PSMA targeted molecular probe in prostate cancer has been
widely applied in the diagnosis of disease.
[68Ga]P137 is a novel PSMA targeted molecular probe labeled with 68Ga. DOTA is used as a
bifunctional linker to coordinate with 68Ga3+. The labeling method is simple, the biological
stability is high, the tumor site has obvious radioactive enrichment, and the imaging effect
is superior.This project provides research on [68Ga]P137 PET/CT imaging for patients with
suspected PCa, and provides basis for early diagnosis of PCa, formulation of treatment plan
and efficacy evaluation.