Prostate Cancer Clinical Trial
Official title:
Evaluation of the Incidence and Prevalence of Sarcopenia in Patients 70 Year and Older With Localized and Locally Advanced Porstate Cancer, Treated by Radiotherapy and Androgen Deprivation Therapy. a Monocentric Cohort Trial
Prostate cancer is the most common cancer among men 50 years and older and mainly affets
patients 75 years old.
Androgen deprivation therapy is indicatated in intermediates and high risks form of prostate
cancer, in association with radiotherapy for 6 monts to 3 years. It is also indicated after
surgery. Current therapies induce inhibition of sexual hormones as androgens among which
testosterone. These therapies present side effects which have to be acknowledeged during the
elaboration therapeutic startegies in older patients: hypogonadism induced by androgen
deprivation therapy (ADT) causes loss of bone mineral density, diminution of lean body mass
and increase of fat body mass.
Sarcopenia is defined by a loss of muscle strength associated to a decrease in skeletal
muscle mass. In addition to aging, many factors may contribute to sarcopenia as cancer and/or
ADT. This cohort study aims to evaluate risk factors associated to sarcopenia prevalence and
the relationship between ADT and sarcopenia incidence, in patients 70 years or older with
localized or locally advanced prostate cancer
n/a
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