Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox) — EXIPOX  

Prostate Cancer Clinical Trial

Official title: Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox)-Study - a Pilot Study Exploring Exercise as a Way of Improving Cure With Radical Radiotherapy

Status Terminated

Clinical Trial Summary

Previous research into metabolic and hypoxic markers has found evidence of preclinical impact of exercise on prostate tumor blood flow and oxygenation in rodents . As radiotherapy is a frequently used and effective therapy for and that sufficient oxygenation is decisive to the effect of radiotherapy, an underlying hypothesis that aerobic exercise might improve treatment efficacy of radiotherapy in prostate cancer is put forward. This study has a potential challenging intervention, but a potential very high gain as it includes active patient participation to significantly improve outcome of radical radiotherapy.

Clinical Trial Description

A randomized controlled trial with four to five weeks of moderate/high intensity aerobic exercise program compared with no intervention for 32 prostate cancer patients waiting for radical prostatectomy at the University Hospital of North Norway (UNN). 16 patients will undergo the intervention. The expression of the hypoxic marker pimonidazole in the prostate specimens of intervention groups and the control groups will be assessed. This method is considered a reliable tissue oxygenation measurement technique. These patients will also have their and blood flow and hypoxia measured in prostate cancers through magnetic resonance imaging (MRIs). ;

Related Conditions & MeSH terms

• Hypoxia
• Physical Activity
• Prostate Cancer
• Prostatic Neoplasms

• NCT number: NCT03365076
• Study type: Interventional
• Source: University Hospital of North Norway
• Status: Terminated
• Phase: N/A
• Start date: May 1, 2018
• Completion date: January 5, 2023